Ethyl Pyruvate Protects Colonic Anastomosis From Ischemia-Reperfusion Injury

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dc.authoridEroglu, Ahmet/0000-0002-0396-1582
dc.authoridCanbay, Emel/0000-0001-7592-3000
dc.authoridBilgihan, Ayse/0000-0003-1307-2794
dc.authorwosidDolapçı, Mete/GSD-5477-2022
dc.authorwosidEroglu, Ahmet/B-1414-2012
dc.authorwosidCanbay, Emel/AAA-8582-2022
dc.authorwosidBilgihan, Ayse/AAH-9815-2021
dc.contributor.authorUnal, B.
dc.contributor.authorKarabeyoglu, M.
dc.contributor.authorHuner, T.
dc.contributor.authorCanbay, E.
dc.contributor.authorEroglu, A.
dc.contributor.authorYildirim, O.
dc.contributor.authorDolapci, M.
dc.date.accessioned2024-08-04T20:31:09Z
dc.date.available2024-08-04T20:31:09Z
dc.date.issued2009
dc.departmentİnönü Üniversitesien_US
dc.description.abstractEthyl pyruvate is a simple derivative in Ca+2- and K+-containing balanced salt solution of pyruvate to avoid the problems associated with the instability of pyruvate in solution. It has been shown to ameliorate the effects of ischemia-reperfusion (I/R)injury in many organs. It has also been shown that I/R injury delays the healing of colonic anastomosis. In this study, the effect of ethyl pyruvate on the healing of colon anastomosis and anastomotic strength after I/R injury was investigated. Anastomosis of the colon was performed in 32 adult male Wistar albino rats divided into 4 groups of 8 individuals: (1) sham-operated control group (group 1); (2) 30 minutes of intestinal I/R by superior mesenteric artery occlusion (group 2); (3) I/R+ ethyl pyruvate (group 3), ethyl pyruvate was administered as a 50-mg/kg/d single dose; and (4) I/R+ ethyl pyruvate (group 4), ethyl pyruvate administration was repeatedly (every 6 hours) at the same dose (50 mg/kg). On the fifth postoperative day, animals were killed. Perianastomotic tissue hydroxyproline contents and anastomotic bursting pressures were measured in all groups. When the anastomotic bursting pressures and tissue hydroxyproline contents were compared, it was found that they were decreased in group a when compared with groups 1,3, and 4 (P < .05). Both anastomotic bursting pressure (P = .005) and hydroxyproline content (P < .001) levels were found to be significantly increased with ethyl pyruvate administration when compared with group 2. When ethyl pyruvate administration doses were compared, a significant difference was not observed (P > .05). Ethyl pyruvate significantly prevents the delaying effect of I/R injury on anastomotic strength and healing independent from doses of administration.en_US
dc.identifier.doi10.1177/1553350608328584
dc.identifier.endpage25en_US
dc.identifier.issn1553-3506
dc.identifier.issn1553-3514
dc.identifier.issue1en_US
dc.identifier.pmid19064591en_US
dc.identifier.scopus2-s2.0-63249122303en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage21en_US
dc.identifier.urihttps://doi.org/10.1177/1553350608328584
dc.identifier.urihttps://hdl.handle.net/11616/94772
dc.identifier.volume16en_US
dc.identifier.wosWOS:000264507400006en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Incen_US
dc.relation.ispartofSurgical Innovationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectethyl pyruvateen_US
dc.subjectwound healingen_US
dc.subjectanastomotic bursting pressureen_US
dc.subjecthydroxyproline levelsen_US
dc.subjectischemia-reperfusion injuryen_US
dc.titleEthyl Pyruvate Protects Colonic Anastomosis From Ischemia-Reperfusion Injuryen_US
dc.typeArticleen_US

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