Thymoquinone is protective against 2,3,7,8-tetrachlorodibenzo-p-dioxin induced hepatotoxicity

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dc.authoridGül, Mehmet/0000-0002-1374-0783
dc.authoridGozukara Bag, Harika Gozde/0000-0003-1208-4072
dc.authoridErdemli, Erman/0000-0003-4596-7525
dc.authoridGül, Semir/0000-0002-4668-9603
dc.authoridYigitcan, Birgul/0000-0002-7910-4595
dc.authorwosidGül, Mehmet/ABI-6336-2020
dc.authorwosidGozukara Bag, Harika Gozde/ABG-7588-2020
dc.authorwosidErdemli, Erman/ABI-8193-2020
dc.authorwosidGül, Semir/ABI-8244-2020
dc.authorwosidaksungur, zeynep/AAW-2041-2021
dc.authorwosidYigitcan, Birgul/KUD-3587-2024
dc.contributor.authorErdemli, M. E.
dc.contributor.authorYigitcan, B.
dc.contributor.authorGul, M.
dc.contributor.authorBag, H. G.
dc.contributor.authorGul, S.
dc.contributor.authorAksungur, Z.
dc.date.accessioned2024-08-04T20:44:26Z
dc.date.available2024-08-04T20:44:26Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractWe investigated changes in rat liver tissues following administration of thymoquinone (TQ) against 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induced hepatotoxicity. Fifty rats were assigned randomly to five groups of 10 as follows: control, corn oil, TCDD, TQ and TCDD + TQ. Biochemical and histopathological analyses were conducted on liver tissue. We found that 30 day TCDD administration caused histopathological changes in liver including thickening of Glisson's capsule, intracytoplasmic vacuolization in hepatocytes, sinusoidal dilation, vascular and sinusoidal congestion and inflammatory cell infiltration. TCDD administration increased malondialdehyde (MDA), total oxidant status (TOS), alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) levels in rat liver tissue and reduced glutathione (GSH), superoxide dismutase (SOD), catalase (CAT) and total antioxidant status (TAS) levels compared to all other groups. In the TQ treated group, GSH, SOD, CAT and TAS levels increased compared to all other groups. MDA, TOS, ALT, AST, ALP levels decreased compared to all other groups. Our histological findings were consistent with the biochemical findings. The oxidative and histologic effects of TCDD were eliminated by TQ treatment. TCDD administration caused oxidative stress in rat liver and TQ administered with TCDD prevented TCDD induced hepatotoxicity. TQ could be considered an alternative anti-TCDD toxicity agent.en_US
dc.identifier.doi10.1080/10520295.2018.1453549
dc.identifier.endpage462en_US
dc.identifier.issn1052-0295
dc.identifier.issn1473-7760
dc.identifier.issue6en_US
dc.identifier.pmid29701106en_US
dc.identifier.scopus2-s2.0-85046014435en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage453en_US
dc.identifier.urihttps://doi.org/10.1080/10520295.2018.1453549
dc.identifier.urihttps://hdl.handle.net/11616/98253
dc.identifier.volume93en_US
dc.identifier.wosWOS:000447625300007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofBiotechnic & Histochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjecthepatotoxicityen_US
dc.subjectliveren_US
dc.subjectoxidative stressen_US
dc.subject2en_US
dc.subject3en_US
dc.subject7en_US
dc.subject8-tetrachlorodibenzo-p-dioxinen_US
dc.subjectthymoquinoneen_US
dc.titleThymoquinone is protective against 2,3,7,8-tetrachlorodibenzo-p-dioxin induced hepatotoxicityen_US
dc.typeArticleen_US

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