Effects of formaldehyde inhalation on humoral immunity and protective effect of Nigella sativa oil: An experimental study

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dc.authoridKose, Evren/0000-0002-0246-2589
dc.authoridOgeturk, Murat/0000-0002-5744-4812
dc.authorwosidKose, Evren/ABG-9908-2020
dc.authorwosidOgeturk, Murat/B-3444-2008
dc.contributor.authorSapmaz, Hilal Irmak
dc.contributor.authorSarsilmaz, Mustafa
dc.contributor.authorGodekmerdan, Ahmet
dc.contributor.authorOgeturk, Murat
dc.contributor.authorTas, Ufuk
dc.contributor.authorKose, Evren
dc.date.accessioned2024-08-04T20:42:37Z
dc.date.available2024-08-04T20:42:37Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAim: This study was carried out to determine the effects of formaldehyde (FA) inhalation on the humoral immunity of rats and the protective effect of Nigella sativa (NS) oil. Materials and Methods: The rats (n = 33) were divided into five groups, with five animals in the control group (FA-free air) and seven in the other four groups. Group FA I was exposed to FA (5 ppm), group FA NS I was treated with NS and exposed to FA (5 ppm), group FA2 was exposed to FA (10 ppm), and group FA + NS2 was treated with NS and exposed to FA (10 ppm). At the end of a 4-week study period, blood samples were collected. Enzyme-linked immunosorbent assay was used to determine the levels of serum total immunoglobulin A (IgA), total immunoglobulin M (IgM), total immunoglobulin G (IgG), and complement 3 (C3). Results: FA inhalation significantly increased serum IgA, IgM, and C3 levels and decreased serum IgG levels compared with the control group. NS administration decreased serum IgA, IgM, and C3 levels, which were induced by FA inhalation. Conclusion: FA inhalation significantly increased acute antibody responses and C3 levels in a dose-dependent manner compared with the control group. FA inhalation decreased the secondary immune response compared with the control group. Levels of acute antibody responses and complement following exposure to FA inhalation returned to normal following treatment with NS (immunoregulatory effect). However, NS did not affect the secondary immune response.en_US
dc.identifier.doi10.1177/0748233714566294
dc.identifier.endpage1569en_US
dc.identifier.issn0748-2337
dc.identifier.issn1477-0393
dc.identifier.issue9en_US
dc.identifier.pmid25653037en_US
dc.identifier.scopus2-s2.0-84983591644en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1564en_US
dc.identifier.urihttps://doi.org/10.1177/0748233714566294
dc.identifier.urihttps://hdl.handle.net/11616/97485
dc.identifier.volume32en_US
dc.identifier.wosWOS:000381953900003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Incen_US
dc.relation.ispartofToxicology and Industrial Healthen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFormaldehydeen_US
dc.subjecthumoral immunityen_US
dc.subjectNigella sativa oilen_US
dc.subjecttotal immunoglobulinen_US
dc.subjectELISAen_US
dc.titleEffects of formaldehyde inhalation on humoral immunity and protective effect of Nigella sativa oil: An experimental studyen_US
dc.typeArticleen_US

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