The effect of adrenomedullin and cold stress on interleukin-6 levels in some rat tissues

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dc.authoridYurekli, Muhittin/0000-0002-5830-8564
dc.authorwosidYurekli, Muhittin/B-4414-2016
dc.contributor.authorYildirim, N. C.
dc.contributor.authorYurekli, M.
dc.date.accessioned2024-08-04T20:32:24Z
dc.date.available2024-08-04T20:32:24Z
dc.date.issued2010
dc.departmentİnönü Üniversitesien_US
dc.description.abstractP>Stress known to stimulate sympathetic activity, as well as the hypothalamic-pituitary-adrenal axis (HPA), produces a significant increase in adrenomedullin (AdM) levels, suggesting a regulatory or protective role for AdM in countering HPA activation that follows a variety of stressors. Stressors can modulate the secretion of proinflammatory cytokines. Interleukin (IL)-6 is a potent activator of the HPA and appears to play a pathogenic role in conditions related to stress. In the present study, we investigated the administration of AdM on IL-6 levels in cold exposed rats. Male Wistar rats were divided into four groups as control, adrenomedullin treatment, cold stress and cold stress+adrenomedullin-treated groups. In the adrenomedullin-treated group, animals received intraperitoneal (i.p.) injection of adrenomedullin (2000 ng/kg body weight) once a day for a week. For the cold stress exposure the rats were kept in separate cages at 10 degrees C for a week. Control group rats were kept in laboratory conditions. The concentration of IL-6 was determined using an enzyme-linked immunosorbent assay (ELISA) kit. When compared to control, IL-6 levels increased significantly in the cold stress- and adrenomedullin-treated groups (P < 0 center dot 05). Administration of AdM in addition to cold stress decreased IL-6 levels in lung and liver, but increased in brain and heart when compared to control (P < 0 center dot 05). The results suggest that cold stress may induce increase of rat proinflammatory cytokine IL-6 and adrenomedullin may play a regulatory or protective role for cold stress.en_US
dc.description.sponsorshipInonu University [2006/42]en_US
dc.description.sponsorshipThe animal experiments were carried out in accordance with the guidelines for animal research from the National Institute of Health and were approved by the Committee of Animal Research at Inonu University, Malatya, Turkey (2007/51). This research was funded by Inonu University, Project no: 2006/42. There are no conflicts of interest. No company or institution might benefit from the publication.en_US
dc.identifier.doi10.1111/j.1365-2249.2010.04156.x
dc.identifier.endpage175en_US
dc.identifier.issn0009-9104
dc.identifier.issn1365-2249
dc.identifier.issue1en_US
dc.identifier.pmid20456410en_US
dc.identifier.scopus2-s2.0-77953236577en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage171en_US
dc.identifier.urihttps://doi.org/10.1111/j.1365-2249.2010.04156.x
dc.identifier.urihttps://hdl.handle.net/11616/95052
dc.identifier.volume161en_US
dc.identifier.wosWOS:000278396900021en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofClinical and Experimental Immunologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectadrenomedullinen_US
dc.subjectcold-stressen_US
dc.subjectcytokineen_US
dc.subjectinterleukinen_US
dc.subjectraten_US
dc.titleThe effect of adrenomedullin and cold stress on interleukin-6 levels in some rat tissuesen_US
dc.typeArticleen_US

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