Protonated water-soluble N-heterocyclic carbene ruthenium(II) complexes: Synthesis, cytotoxic and DNA binding properties and molecular docking study

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dc.authoridBALCIOGLU, Sevgi/0000-0003-0724-4772
dc.authoridBALCIOGLU, Sevgi/0000-0003-0724-4772
dc.authoridTASKIN TOK, Tugba/0000-0002-0064-8400
dc.authoridAteş, Burhan/0000-0001-6080-229X
dc.authoridAKKOÇ, Mitat/0000-0001-8641-8958
dc.authoridGürses, Canbolat/0000-0002-4085-0224
dc.authoridYaşar, Sedat/0000-0001-7285-2761
dc.authorwosidBALCIOGLU, Sevgi/W-5874-2018
dc.authorwosidBALCIOGLU, Sevgi/O-3576-2015
dc.authorwosidTASKIN TOK, Tugba/A-8885-2016
dc.authorwosidAteş, Burhan/AAA-3730-2021
dc.authorwosidAKKOÇ, Mitat/AAJ-5780-2020
dc.authorwosidGürses, Canbolat/AAA-6825-2019
dc.authorwosidYaşar, Sedat/ABG-8356-2020
dc.contributor.authorAkkoc, Mitat
dc.contributor.authorBalcioglu, Sevgi
dc.contributor.authorGurses, Canbolat
dc.contributor.authorTok, Tugba Taskin
dc.contributor.authorAtes, Burhan
dc.contributor.authorYasar, Sedat
dc.date.accessioned2024-08-04T20:44:34Z
dc.date.available2024-08-04T20:44:34Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractNew benzimidazolium salts 1a-d having methylpyridine group on the side chain, have been synthesized and reacted with Ag2O to produce Ag(I)-N-heterocyclic carbene (NHC) complexes 2a-d. Ag(I)-N-heterocyclic carbene (NHC) complexes were used as a carben transfer agents to synthesize water-soluble ruthenium(II)-NHC complexes 4a-d. All synthesized compounds were fully characterized by H-1 and C-13 NMR and HRMS spectroscopic techniques. Anticancer potential and IC50 values of ruthenium(II)-NHC complexes were evaluated by MTT assay against human colorectal cancer (Caco-2) and breast cancer (MCF-7) cell lines. The IC50 value of water-soluble ruthenium(II)-NHC complex 4d demonstrated remarkable cytotoxic activity against Caco-2 (18.0 +/- 1) and MCF-7 (23.8 +/- 0.5) cell lines. Also, 4d has better DNA binding capacity than 4a-c. DS 2017 R2 was used to exert molecular docking for understanding interactions between the water-soluble ruthenium(II)-NHC complexes and DNA. These complexes have been highlighted as a new type of drug. (C) 2018 Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey TUBITAK [114Z036]en_US
dc.description.sponsorshipThis work was financially supported by The Scientific and Technological Research Council of Turkey TUBITAK (Project No: 114Z036).en_US
dc.identifier.doi10.1016/j.jorganchem.2018.06.003
dc.identifier.endpage74en_US
dc.identifier.issn0022-328X
dc.identifier.issn1872-8561
dc.identifier.scopus2-s2.0-85048262138en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage67en_US
dc.identifier.urihttps://doi.org/10.1016/j.jorganchem.2018.06.003
dc.identifier.urihttps://hdl.handle.net/11616/98329
dc.identifier.volume869en_US
dc.identifier.wosWOS:000437721800008en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Science Saen_US
dc.relation.ispartofJournal of Organometallic Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnticancer activityen_US
dc.subjectDNA bindingen_US
dc.subjectN-heterocyclic carbeneen_US
dc.subjectRutheniumen_US
dc.subjectWater soluble complexen_US
dc.titleProtonated water-soluble N-heterocyclic carbene ruthenium(II) complexes: Synthesis, cytotoxic and DNA binding properties and molecular docking studyen_US
dc.typeArticleen_US

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