The efficacy of hesperidin for treatment of acute otitis media

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dc.authoridAlan, Saadet/0000-0003-2329-151X
dc.authoridbasak, nese/0000-0001-5566-8321
dc.authoridCetinkaya, Erdem/0000-0001-6911-5795
dc.authorwosidAlan, Saadet/ABH-4282-2020
dc.authorwosidbasak, nese/ABH-5495-2020
dc.authorwosidCetinkaya, Erdem/AAD-1656-2019
dc.contributor.authorCetinkaya, Erdem Atalay
dc.contributor.authorCiftci, Osman
dc.contributor.authorAlan, Saadet
dc.contributor.authorOztanir, M. Namik
dc.contributor.authorBasak, Nese
dc.date.accessioned2024-08-04T20:45:21Z
dc.date.available2024-08-04T20:45:21Z
dc.date.issued2019
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjectives: In this experimental study, the effect of hesperidin on the treatment of acute otitis media (AOM) was investigated in an AOM-induced rat model. Methods: In total, 35 rats were randomly divided into the following five groups (n = 7): group 1 (control), group 2 (AOM with no treatment), group 3 (AOM + antibiotic), group 4 (AOM + hesperidin), and group 5 (AOM + hesperidin + antibiotic). On day 14, group 3,4 and 5 rats were given antibiotic and hesperidin via gavages, respectively. Histopathological and immunological analyses were performed and the results analyzed. Results: Serum levels of TNE-alpha, IL-4, IL-6 and IL-beta were significantly decreased in the hesperidin- and antibiotic-treated groups compared to the AOM group. The AOM + antibiotic and AOM + hesperidin groups demonstrated reduced histological damage compared to the AOM group. Between the AOM + antibiotic and AOM + hesperidin groups, significant differences in tympanic membrane thickness(ThicTM), inflammation(Inf), and sclerosis(Sc) values were observed. However, no difference in epithelial damage(DamEpith), was seen between the two groups. There was a significant difference in the AOM + antibiotic and AOM + antibiotic + hesperidin groups compared to AOM group (P < 0.001). Conclusions: In this study, we observed that both antibiotic and hesperidin treatment reduced AOM symptoms in an AOM-induced rat model. The values in AOM + antibiotic + hesperidin group were markedly lower than those of the other groups. From our results, we propose that hesperidin, in combination with antibiotics, may provide a successful alternative treatment for AOM compared with antibiotics used alone. (C) 2018 Elsevier B.V. All rights reserved.en_US
dc.identifier.doi10.1016/j.anl.2018.07.005
dc.identifier.endpage177en_US
dc.identifier.issn0385-8146
dc.identifier.issn1879-1476
dc.identifier.issue2en_US
dc.identifier.pmid30072162en_US
dc.identifier.scopus2-s2.0-85050616669en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage172en_US
dc.identifier.urihttps://doi.org/10.1016/j.anl.2018.07.005
dc.identifier.urihttps://hdl.handle.net/11616/98400
dc.identifier.volume46en_US
dc.identifier.wosWOS:000463846800004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Sci Ltden_US
dc.relation.ispartofAuris Nasus Larynxen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHesperidinen_US
dc.subjectAcute otitis mediaen_US
dc.subjectHistological examinationen_US
dc.subjectCytokinesen_US
dc.subjectRatsen_US
dc.titleThe efficacy of hesperidin for treatment of acute otitis mediaen_US
dc.typeArticleen_US

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