Small-dose capsaicin reduces systemic inflammatory responses in septic rats

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dc.authoridErsoy, Mehmet/0000-0002-0724-2825;
dc.authorwosidErsoy, Mehmet/ACN-2779-2022
dc.authorwosidGürbüz, Necla/H-8965-2018
dc.authorwosidKARAMAN, Abdurrahman/G-7825-2016
dc.contributor.authorDemirbilek, S
dc.contributor.authorErsoy, MO
dc.contributor.authorDemirbilek, S
dc.contributor.authorKaraman, A
dc.contributor.authorGürbüz, N
dc.contributor.authorBayraktar, N
dc.contributor.authorBayraktar, M
dc.date.accessioned2024-08-04T20:31:11Z
dc.date.available2024-08-04T20:31:11Z
dc.date.issued2004
dc.departmentİnönü Üniversitesien_US
dc.description.abstractWe investigated the influence of small- and large-dose capsaicin in modulating systemic inflammatory responses during different stages of sepsis in rats. Rats were divided into six groups: group C, control; group S, sepsis; group CLC, small dose of capsaicin (1 mg/kg subcutaneously); group SLC, small dose of capsaicin plus sepsis; group CHC, large dose of capsaicin (150 mg/kg subcutaneously); group SHC, large dose of capsaicin plus sepsis. Rats were made septic by cecal ligation and puncture (CLP). Each group was subdivided into two subgroups. The animals were killed at 9 or 18 h after CLP. Plasma concentrations of calcitonin gene-related peptide (CGRP), tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, IL-10, and total nitrite/nitrate (NOx) were measured. Superoxide dismutase and malondialdehyde (MDA) were determined in liver, lung, and heart tissues. CGRP was increased in groups S, CLC, and SLC when compared with the other groups. In the SLC group, plasma concentrations of TNF-alpha, IL-6, NOx, and tissue MDA levels were reduced and IL-10 level was increased when compared with groups S and SHC 18 h after CLP (P < 0.05). Small-dose capsaicin treatment increased antiinflammatory IL-10 levels and attenuated the increases in proinflammatory cytokines, NOx, and tissue MDA in septic rats.en_US
dc.identifier.doi10.1213/01.ANE.0000132975.02854.65
dc.identifier.endpage1507en_US
dc.identifier.issn0003-2999
dc.identifier.issue5en_US
dc.identifier.pmid15502055en_US
dc.identifier.scopus2-s2.0-6444243612en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage1501en_US
dc.identifier.urihttps://doi.org/10.1213/01.ANE.0000132975.02854.65
dc.identifier.urihttps://hdl.handle.net/11616/94784
dc.identifier.volume99en_US
dc.identifier.wosWOS:000224684400040en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofAnesthesia and Analgesiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGene-Related Peptideen_US
dc.subjectNitric-Oxideen_US
dc.subjectSepsisen_US
dc.subjectMacrophagesen_US
dc.subjectExpressionen_US
dc.subjectCurcuminen_US
dc.subjectNitrateen_US
dc.subjectAssayen_US
dc.subjectShocken_US
dc.titleSmall-dose capsaicin reduces systemic inflammatory responses in septic ratsen_US
dc.typeArticleen_US

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