Protective effects of dexpanthenol in an experimental model of necrotizing enterocolitis

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dc.authoridPolat, Alaadin/0000-0002-6920-3856
dc.authoridParlakpinar, Hakan/0000-0001-9497-3468
dc.authoridTaslidere, Elif/0000-0003-1723-2556
dc.authoridParlakpınar, Hakan/0000-0001-9497-3468
dc.authoridPolat, Alaadin/0000-0002-6920-3856
dc.authoridVardı, Nigar/0000-0003-0576-1696
dc.authorwosidPolat, Alaadin/Q-4052-2018
dc.authorwosidParlakpinar, Hakan/V-6637-2019
dc.authorwosidTaslidere, Elif/ABI-8046-2020
dc.authorwosidParlakpınar, Hakan/T-6517-2018
dc.authorwosidKARAMAN, Abdurrahman/G-7825-2016
dc.authorwosidPolat, Alaadin/AAA-7171-2021
dc.authorwosidVardı, Nigar/C-9549-2018
dc.contributor.authorKaradag, Ahmet
dc.contributor.authorOzdemir, Ramazan
dc.contributor.authorKurt, Ahmet
dc.contributor.authorParlakpinar, Hakan
dc.contributor.authorPolat, Alaadin
dc.contributor.authorVardi, Nigar
dc.contributor.authorTaslidere, Elif
dc.date.accessioned2024-08-04T20:41:22Z
dc.date.available2024-08-04T20:41:22Z
dc.date.issued2015
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground/purpose: In pathogenesis of necrotizing enterocolitis (NEC), both oxidative stress and inflammation are considerable risk factors. The study was designed to evaluate whether administration of dexpanthenol (Dxp) is able to attenuate intestinal injury through the antioxidant and antiinflammatory mechanisms in a neonatal rat model of NEC. Methods: Forty newborn pups divided into four groups were included in the study: control, control + Dxp, NEC, and NEC + Dxp. NEC was induced by hyperosmolar formula and additionally the pups were exposed to hypoxia/hyperoxia and cold stress. They were sacrificed on postnatal day four, and their intestinal tissues were analyzed biochemically and histopathologically. Results: Dxp caused a significant decrease in intestinal damage as determined by the histological score, villus height and number of goblet cells in NEC groups (p < 0.0001). Tissue malondialdehyde, total oxidant status, and oxidative stress indexes levels were higher in the NEC group than in the control and control + Dxp groups (p < 0.001). These values were reduced in the pups treated with Dxp (p <= 0.004). Superoxide dismutase, glutathione peroxidase, and reduced glutathione activities were significantly reduced in the NEC group compared to the others (p < 0.005). Treatmentwith Dxp significantly reduced elevations in tissue homogenate levels of tumor necrosis factor-alpha and interleukin-1 beta in the NEC + Dxp group (p = 0.002 and p = 0.01, respectively). Conclusions: Dexpanthenol seems to have antiinflammatory and antioxidant properties. Prophylaxis with Dxp has a potential to reduce the severity of intestinal damage in NEC in the animals. (C) 2015 Elsevier Inc. All rights reserved.en_US
dc.description.sponsorshipInonu University Department of Scientific Research Projects [2013/124]en_US
dc.description.sponsorshipWe are grateful to Prof. Dr. Saim Yologlu, Department of Biostatistics, Inonu University, for his polite help in the statistical analysis. We are also grateful to Inonu University Department of Scientific Research Projects (Project No.: 2013/124), for it was financial support.en_US
dc.identifier.doi10.1016/j.jpedsurg.2014.10.053
dc.identifier.endpage1124en_US
dc.identifier.issn0022-3468
dc.identifier.issn1531-5037
dc.identifier.issue7en_US
dc.identifier.pmid25783305en_US
dc.identifier.scopus2-s2.0-84952628763en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1119en_US
dc.identifier.urihttps://doi.org/10.1016/j.jpedsurg.2014.10.053
dc.identifier.urihttps://hdl.handle.net/11616/97090
dc.identifier.volume50en_US
dc.identifier.wosWOS:000360120200009en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherW B Saunders Co-Elsevier Incen_US
dc.relation.ispartofJournal of Pediatric Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNecrotizing enterocolitisen_US
dc.subjectDexpanthenolen_US
dc.subjectPantothenic aciden_US
dc.subjectAntioxidanten_US
dc.subjectReactive oxygen speciesen_US
dc.titleProtective effects of dexpanthenol in an experimental model of necrotizing enterocolitisen_US
dc.typeArticleen_US

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