Influence of ABCB1 polymorphisms and serum concentrations on venlafaxine response in patients with major depressive disorder

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dc.authoridOZBEY, GUL/0000-0002-3616-0052
dc.authoridPercin, Ferda Emriye/0000-0001-9317-8155
dc.authorwosidOZBEY, GUL/B-7783-2009
dc.authorwosidOZBEY, GUL/H-3620-2012
dc.authorwosidUluoglu, Canan/AIE-4121-2022
dc.authorwosidPercin, Ferda Emriye/H-6850-2016
dc.contributor.authorOzbey, Gul
dc.contributor.authorCelikel, Feryal Cam
dc.contributor.authorCumurcu, Birgul Elbozan
dc.contributor.authorKan, Derya
dc.contributor.authorYucel, Berna
dc.contributor.authorHasbek, Ekrem
dc.contributor.authorPercin, Ferda
dc.date.accessioned2024-08-04T20:42:54Z
dc.date.available2024-08-04T20:42:54Z
dc.date.issued2017
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: The pharmacokinetics and the pharmacodynamics of antidepressants show large inter-individual variations which result in unpredictable clinical responses.Aim: The aim of the study was to examine the effect of ABCB1 polymorphisms and the serum concentrations on the efficacy and tolerability of venlafaxine in patients with major depressive disorder (MDD).Methods: Fifty-two outpatients who met the Diagnostic and Statistical Manual of Mental Disorders Fourth Edition (DSM-IV) criteria for MDD were recruited for the study. The severity of depression was assessed using the 17-item Hamilton Rating Scale for Depression scale (HDRS17) and tolerability was assessed based on a query regarding side-effects for 6 weeks. The ABCB1 C3435T/A and G2677T/A polymorphisms were genotyped by PCR/RFLP and steady-state serum venlafaxine concentrations were measured by high-performance liquid chromatography.Results: Patients with the TT genotype for the C3435T and the TT/TA genotype for the G2677T/A polymorphism showed significantly higher frequencies in venlafaxine-induced akathisia. This relationship was not observed for efficacy. As regards serum venlafaxine concentrations, patient groups showed no significant differences in efficacy and tolerability.Conclusion: The results suggest that individuals with the TT-TT/TA genotypes for the C3435T-G2677T/A polymorphisms of ABCB1 may be pre-disposed to a risk of akathisia.en_US
dc.description.sponsorshipScientific Research Projects of Gaziosmanpasa University, Turkey [2007/36]en_US
dc.description.sponsorshipThis study was supported by grants from the Scientific Research Projects of Gaziosmanpasa University (Project No: 2007/36), Turkey.en_US
dc.identifier.doi10.1080/08039488.2016.1268203
dc.identifier.endpage237en_US
dc.identifier.issn0803-9488
dc.identifier.issn1502-4725
dc.identifier.issue3en_US
dc.identifier.pmid28079463en_US
dc.identifier.scopus2-s2.0-85009282348en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage230en_US
dc.identifier.urihttps://doi.org/10.1080/08039488.2016.1268203
dc.identifier.urihttps://hdl.handle.net/11616/97662
dc.identifier.volume71en_US
dc.identifier.wosWOS:000399501200010en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofNordic Journal of Psychiatryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectABCB1 polymorphismen_US
dc.subjectakathisiaen_US
dc.subjectserum concentrationen_US
dc.subjectvenlafaxineen_US
dc.subjectresponseen_US
dc.titleInfluence of ABCB1 polymorphisms and serum concentrations on venlafaxine response in patients with major depressive disorderen_US
dc.typeArticleen_US

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