Cerebrospinal fluid leptin levels in preeclampsia: relation to maternal serum leptin levels

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dc.authorwosidÖZEROL, ELİF/AAA-6707-2021
dc.contributor.authorCelik, O
dc.contributor.authorHascalik, S
dc.contributor.authorOzerol, E
dc.contributor.authorHascalik, M
dc.contributor.authorYologlu, S
dc.date.accessioned2024-08-04T20:15:02Z
dc.date.available2024-08-04T20:15:02Z
dc.date.issued2004
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: To determine whether cerebrospinal fluid (CSF) and circulating levels of leptin differ between women with preeclampsia and women who had an uncomplicated pregnancy. Methods: Maternal serum and CSF leptin concentrations obtained in the third trimester of the gestation were compared in 16 women with mild preeclampsia and 23 normotensive pregnant women who underwent cesarean section. Before administering local anesthetic for spinal anesthesia, 2 mL CSF and 4 mL venous blood sample were taken and were stored at -30 degreesC until serum and CSF leptin levels were measured by enzyme-linked immunosorbent assay (ELISA). Results: Mean CSF leptin concentrations were not significantly different between the two groups (preeclampsia 9.7 +/- 4.2 ng/mL, normotensive 13.6 +/- 4.3 ng/mL, p = 0.952). Similarly, mean serum leptin concentrations were similar between the two groups (mild preeclampsia 21.7 +/- 7.1 ng/mL, normotensive 18.3 +/- 6.7 ng/mL, p = 0.698). CSF leptin levels are inversely related to the serum leptin concentrations in preeclamptic patients (r = -0.87, p = 0.000). An inverse relationship was also detected between CSF and serum leptin levels in normotensive pregnant subjects (r = -0.66, p = 0.000). Conclusions: CSF and serum leptin levels were similar in patients with preeclampsia and normotensive pregnant women. However, the CSF leptin was negatively correlated with the serum leptin concentrations in preeclamptic and normotensive control subjects, suggesting that leptin enters the brain by a saturable transport system. Further work is needed to confirm our findings.en_US
dc.identifier.doi10.1111/j.0001-6349.2004.00325.x
dc.identifier.endpage523en_US
dc.identifier.issn0001-6349
dc.identifier.issn1600-0412
dc.identifier.issue6en_US
dc.identifier.pmid15144331en_US
dc.identifier.scopus2-s2.0-2542637107en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage519en_US
dc.identifier.urihttps://doi.org/10.1111/j.0001-6349.2004.00325.x
dc.identifier.urihttps://hdl.handle.net/11616/94106
dc.identifier.volume83en_US
dc.identifier.wosWOS:000221350000002en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofActa Obstetricia Et Gynecologica Scandinavicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectcerebrospinal fluiden_US
dc.subjectleptinen_US
dc.subjectpreeclampsiaen_US
dc.subjectpregnancyen_US
dc.titleCerebrospinal fluid leptin levels in preeclampsia: relation to maternal serum leptin levelsen_US
dc.typeArticleen_US

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