The impact of ellagic acid on some apoptotic gene expressions: a new perspective for the regulation of pancreatic Nrf-2/NF-?B and Akt/VEGF signaling in CCl4-induced pancreas damage in rats

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dc.authoridBEYAZ, SEDA/0000-0003-0436-8112
dc.authoridGök, Özlem/0000-0001-8521-6369
dc.authoridBeyaz, Seda/0000-0003-0436-8112
dc.authoridAslan, Abdullah/0000-0002-6243-4221
dc.authoridCan, Muhammed Ismail/0000-0002-0118-2278
dc.authorwosidBEYAZ, SEDA/ABI-5835-2020
dc.authorwosidGök, Özlem/AFV-8223-2022
dc.authorwosidCan, Muhammed İsmail/ABG-8646-2020
dc.authorwosidcan, mi/KDN-4165-2024
dc.authorwosidBeyaz, Seda/ABD-1252-2021
dc.authorwosidAslan, Abdullah/C-9523-2016
dc.contributor.authorAslan, Abdullah
dc.contributor.authorBeyaz, Seda
dc.contributor.authorGok, Ozlem
dc.contributor.authorCan, Muhammed Ismail
dc.contributor.authorErman, Fazilet
dc.contributor.authorErman, Orhan
dc.date.accessioned2024-08-04T20:49:15Z
dc.date.available2024-08-04T20:49:15Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: The aim of this study was to evaluate the potential effect of ellagic acid (EA) in the treatment of pancreatic injury. EA has been found to have strong anti-inflammatory, antioxidative, and anticancer properties. The effects of EA on pancreatic star cell (PSC) activation and cell functions have been evaluated and it has been shown that it inhibits the activation of basic cell functions and PSCs and(.) it has antidiabetic activity through its effect on beta-pancreas cells. Materials and methods: In this work, 36 Wistar albino rats (n = 36, 8 weeks old) were used. Rats were divided to 4 groups and 9 rats were each group. Groups: Group 1: control group; Group 2: EA group; Group 3: carbon tetrachloride (CCl4) group; Group 4: EA + CCl4 group. Animals were decapitated after 8 weeks and their pancreas tissue samples were taken and researched. In pancreas tissue, NF-kappa B, TNF-alpha, Nrf-2, VEGF, Bcl-2, caspase-3, and Akt proteins expression ratios were analyzed by western blotting method, CAT activity and GSH levels were determined by spectrophotometer and ROS production was detected by MDA. Results: In our results, the Nrf-2 and caspase-3 protein expressions, catalase activities and GSH levels increased, TNF-alpha, NF-kappa B, Bcl-2, VEGF, and Akt protein expressions and MDA levels reduced in EA + CCl4 group comparable to the CCl4 group. Conclusions: These findings reveal that EA decreases pancreas tissue injury in rats and that EA may also be used as a drug against pancreas tissue injury in the future.en_US
dc.description.sponsorshipFirat University Research Projects Unit (FUBAP)en_US
dc.description.sponsorshipThis work was supported by Firat University Research Projects Unit (FUBAP) [Grant No. FF.16.42].en_US
dc.identifier.doi10.1080/08923973.2020.1869255
dc.identifier.endpage152en_US
dc.identifier.issn0892-3973
dc.identifier.issn1532-2513
dc.identifier.issue2en_US
dc.identifier.pmid33455449en_US
dc.identifier.scopus2-s2.0-85100034075en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage145en_US
dc.identifier.urihttps://doi.org/10.1080/08923973.2020.1869255
dc.identifier.urihttps://hdl.handle.net/11616/99738
dc.identifier.volume43en_US
dc.identifier.wosWOS:000608320300001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofImmunopharmacology and Immunotoxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectProtein kinase Ben_US
dc.subjectB-cell lymphoma 2en_US
dc.subjectellagic aciden_US
dc.subjectnuclear factor kappa Ben_US
dc.subjectpancreas damageen_US
dc.titleThe impact of ellagic acid on some apoptotic gene expressions: a new perspective for the regulation of pancreatic Nrf-2/NF-?B and Akt/VEGF signaling in CCl4-induced pancreas damage in ratsen_US
dc.typeArticleen_US

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