The role of fecal calprotectin and lactoferrin in the diagnosis of necrotizing enterocolitis

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dc.authoridözyalın, fatma/0000-0001-6486-6389
dc.authoridÖzyalın, Fatma/0000-0001-6486-6389
dc.authorwosidözyalın, fatma/ABA-5258-2020
dc.authorwosidÖzyalın, Fatma/ABC-7193-2020
dc.contributor.authorSelimoglu, Mukadder Ayse
dc.contributor.authorTemel, Ismail
dc.contributor.authorYildirim, Cigdem
dc.contributor.authorOzyalin, Fatma
dc.contributor.authorAktas, Mumtaz
dc.contributor.authorKarabiber, Hamza
dc.date.accessioned2024-08-04T20:36:02Z
dc.date.available2024-08-04T20:36:02Z
dc.date.issued2012
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: Early detection of necrotizing enterocolitis can improve the prognosis, however, there is not a reliable laboratory test to detect either newborns at risk for necrotizing enterocolitis development or those at early stages of the disease. Since fecal lactoferrin and fecal calprotectin are inflammatory markers of gastrointestinal diseases, it was hypothesized that both these biomarkers could be successfully used in the diagnosis of necrotizing enterocolitis. Methods: In a prospective study, fecal lactoferrin and fecal calprotectin concentrations of 14 newborns with necrotizing enterocolitis and consecutively admitted 40 healthy preterm, and 23 healthy full-term newborns were measured with enzyme-linked immunosorbent assay technique. Results: Mean fecal lactoferrin and fecal calprotectin were not different between preterm and full-term newborns (p = .235 and p = .845, respectively), or those who were diagnosed with necrotizing enterocolitis or not (p = .545 and p = .968, respectively). Prevalence of necrotizing enterocolitis was 1.51% (14 of 2734). Stage of the disease did not have a statistical effect on mean levels (p = .694 and p = .267, respectively). Mean fecal lactoferrin and fecal calprotectin levels were not different in the case of breast-feeding (p = .623 and p = .792, respectively). Conclusion: Neither fecal lactoferrin nor fecal calprotectin has a role in the identification of necrotizing enterocolitis, especially in early stages of the disease. Further studies on wider necrotizing enterocolitis series are needed for a more definite conclusion. (Pediatr Crit Care Med 2012; 13:452-454)en_US
dc.description.sponsorshipInonu University Scientific Research Projects Unit [2007/15]en_US
dc.description.sponsorshipSupported, in part, by Inonu University Scientific Research Projects Unit (No: 2007/15).en_US
dc.identifier.doi10.1097/PCC.0b013e3182388ae9
dc.identifier.endpage454en_US
dc.identifier.issn1529-7535
dc.identifier.issue4en_US
dc.identifier.pmid22079952en_US
dc.identifier.scopus2-s2.0-84864286622en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage452en_US
dc.identifier.urihttps://doi.org/10.1097/PCC.0b013e3182388ae9
dc.identifier.urihttps://hdl.handle.net/11616/95739
dc.identifier.volume13en_US
dc.identifier.wosWOS:000306114300022en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofPediatric Critical Care Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcalprotectinen_US
dc.subjectfecalen_US
dc.subjectlactoferrinen_US
dc.subjectnecrotizing enterocolitisen_US
dc.titleThe role of fecal calprotectin and lactoferrin in the diagnosis of necrotizing enterocolitisen_US
dc.typeArticleen_US

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