The rs3768777-G allele of ITGAV gene is associated with rheumatoid arthritis

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dc.authoridYolbaş, Servet/0000-0001-8516-9769
dc.authoridGozel, Nevzat/0000-0001-7326-6860
dc.authorwosidkargün, kürşat/W-9574-2018
dc.authorwosidYolbaş, Servet/ABI-5312-2020
dc.contributor.authorKoca, Suleyman Serdar
dc.contributor.authorKara, Murat
dc.contributor.authorOzgen, Metin
dc.contributor.authorDagli, Mustafa Necati
dc.contributor.authorGozel, Nevzat
dc.contributor.authorYolbas, Servet
dc.contributor.authorGundogdu, Baris
dc.date.accessioned2024-08-04T20:39:42Z
dc.date.available2024-08-04T20:39:42Z
dc.date.issued2014
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIntegrin alpha v beta 3 (vitronectin receptor) plays a prominent role in angiogenesis, a key pathogenic feature of rheumatoid arthritis (RA). Moreover, integrin alpha(V) (ITGAV) subunit gene has been associated with a susceptibility to RA. The aim of the present study was to detect the potential association between ITGAV gene polymorphisms and a susceptibility to RA in a Turkish cohort. DNA samples were harvested from 160 patients with RA and 144 healthy controls (HC). Three single-nucleotide polymorphisms of ITGAV gene (rs3738919, rs3768777, and rs10174098) were genotyped using real-time PCR. Serum vitronectin levels were analyzed in 30 RA patients, 28 Beh double dagger et's disease (BD) patients, and 30 HC subjects. There was no significant difference between the RA and HC groups in terms of the genotypic and allelic distributions of rs3738919 and rs10174098 polymorphisms. However, the prevalence of rs3768777-G allele was higher in the RA group than in the HC group (OR 2.3, 95 % CI 1.6-3.2, p < 0.0001). Moreover, there was a significant association between RA and the genotypic distribution of rs3768777 (GG + AG vs. AA: OR 2.1, 95 % CI 1.3-3.4; GG vs. AG + AA: OR 4.1, 95 % CI 2.1-7.8). Serum vitronectin levels were lower in the RA and BD groups than in the HC group (p (ANOVA) = 0.002). The rs3738919 and rs10174098 polymorphisms of the ITGAV gene seem not to be associated with susceptibility to RA in Turkish patients. However, rs3768777 increases the risk of RA in this group. These results suggest that the ITGAV gene may be a candidate gene for the etiopathogenesis of RA.en_US
dc.description.sponsorshipTurkish Society of Rheumatologyen_US
dc.description.sponsorshipThis study was supported by the Turkish Society of Rheumatology.en_US
dc.identifier.doi10.1007/s00296-013-2925-7
dc.identifier.endpage698en_US
dc.identifier.issn0172-8172
dc.identifier.issn1437-160X
dc.identifier.issue5en_US
dc.identifier.pmid24375314en_US
dc.identifier.scopus2-s2.0-84901310710en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage693en_US
dc.identifier.urihttps://doi.org/10.1007/s00296-013-2925-7
dc.identifier.urihttps://hdl.handle.net/11616/96459
dc.identifier.volume34en_US
dc.identifier.wosWOS:000335160000015en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofRheumatology Internationalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectRheumatoid arthritisen_US
dc.subjectVitronectinen_US
dc.subjectITGAV geneen_US
dc.titleThe rs3768777-G allele of ITGAV gene is associated with rheumatoid arthritisen_US
dc.typeArticleen_US

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