Comparison of the efficacies of polycaprolactone filler and lidocaine-added filler on neocollagenesis in a rat model

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dc.authoridZAYMAN, EMRAH/0000-0002-6578-3371
dc.authoridSezer, Suat/0000-0002-7462-7485
dc.contributor.authorSezer, Suat
dc.contributor.authorSarac, Gulbahar
dc.contributor.authorGul, Mehmet
dc.contributor.authorZayman, Emrah
dc.contributor.authorKapicioglu, Yelda
dc.date.accessioned2024-08-04T20:50:54Z
dc.date.available2024-08-04T20:50:54Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground Polycaprolactone (PCL) is a semi-permanent filler stimulating neocollagenesis. Lidocaine is frequently used to reduce the pain and, however, may have negative effects on collagen. It was aimed to compare the histological changes on rat skin and efficacies of PCL filler and lidocaine addition. Objective In this study, results of PCL and PCL+Lidocaine application on rat skin were compared using hematoxylin-eosin (H&E) staining, Masson's trichrome (MT) staining, and electron microscope (EM). Methods A total of 30 adult female rats were divided into three groups: the control group, the PCL group, and the PCL+Lidocaine group. The tissue samples taken at months 2 and 4 were examined using H&E, MT, and EM. Results At month 2, dermis thickness, fibroblast count, and collagen fiber diameter increased similarly in the PCL and PCL+Lidocaine groups. Collagen fiber diameter was significantly higher in the PCL group than in the PCL+Lidocaine (p:0.016) and control groups (p:0.009). At month 4, no significant difference was detected between the PCL and PCL+Lidocaine groups in terms of fibroblast count, collagen fiber count, and collagen fiber diameter; dermis thickness was lower in the PCL+Lidocaine group at month 4 (p < 0.46). Dermis thickness, fibroblast count, collagen fiber count, and collagen fiber diameter were found to be significantly lower than in the PCL and PCL+Lidocaine groups. Conclusions Our study showed that lidocaine addition to PCL filler does not affect the efficacy of the filler and PCL filler stimulates neocollagenesis.en_US
dc.identifier.doi10.1111/jocd.14664
dc.identifier.endpage3333en_US
dc.identifier.issn1473-2130
dc.identifier.issn1473-2165
dc.identifier.issue8en_US
dc.identifier.pmid34894046en_US
dc.identifier.scopus2-s2.0-85120918108en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage3327en_US
dc.identifier.urihttps://doi.org/10.1111/jocd.14664
dc.identifier.urihttps://hdl.handle.net/11616/100356
dc.identifier.volume21en_US
dc.identifier.wosWOS:000729097700001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Cosmetic Dermatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectdermal fillersen_US
dc.subjectlidocaineen_US
dc.subjectneocollagenesisen_US
dc.subjectpolycaprolactoneen_US
dc.titleComparison of the efficacies of polycaprolactone filler and lidocaine-added filler on neocollagenesis in a rat modelen_US
dc.typeArticleen_US

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