The effects of intra-operative low-dose dexmedetomidine infusion on postoperative pain in patients undergoing septorhinoplasty

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dc.authorscopusid7004621949
dc.authorscopusid7005217039
dc.authorscopusid6603245381
dc.authorscopusid14036034400
dc.authorscopusid8932188900
dc.authorscopusid7004486274
dc.contributor.authorCicek M.
dc.contributor.authorYucel A.
dc.contributor.authorGedik E.
dc.contributor.authorSagir O.
dc.contributor.authorBut A.K.
dc.contributor.authorErsoy M.O.
dc.date.accessioned2024-08-04T19:59:17Z
dc.date.available2024-08-04T19:59:17Z
dc.date.issued2006
dc.departmentİnönü Üniversitesien_US
dc.description.abstractStudy objective: To determine the effects of intra-operative low-dose dexmedetomidine infusion on postoperative morphine consumption, pain, sedation and patient satisfaction in patients undergoing septorhinoplasty. Method: Fifty adult patients were randomised to receive either dexmedetomidine (a loading dose of 1 ?g kg-1 for the first ten minutes and a maintenance dose of 0.2 ?g kg-1 h-1 afterwards, Group D) or 0.9% saline in the same manner (Group C) after induction of anaesthesia. At the end of the operation, the infusions were discontinued. After extubation, patient controlled analgesia was started intravenously. Results: Patients in Group D consumed 47% less morphine than patients in Group C during the first 24 h and had a lower cumulative morphine consumption at all times after starting patient controlled analgesia (7.08 mg vs. 8.56 mg at 2 h (p < 0.05), 10.84 mg vs. 14.0 mg at 4 h (p < 0.05), 13.56 mg vs. 18.28 mg at 6 h (p < 0.05) and 17.96 mg vs. 33.72 mg at 24 h (p < 0.05), respectively in Group D and Group C). Visual analogue scale scores for pain were higher at all times in Group C than in Group D (p < 0.05). Sedation scores were higher in Group D than in Group C at 30 min after starting patient controlled analgesia (p < 0.05). Patient satisfaction scores were higher at all times in Group D than in Group C (p < 0.05). Conclusions: Intra-operative low-dose dexmedetomidine infusion during septorhinoplasty decreases postoperative morphine consumption, provides effective postoperative pain relief and achieves better patient satisfaction without increased adverse effects. © 2006 VSP.en_US
dc.identifier.doi10.1179/016911106779499028
dc.identifier.endpage402en_US
dc.identifier.issn0169-1112
dc.identifier.issue5-6en_US
dc.identifier.scopus2-s2.0-33846959184en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage395en_US
dc.identifier.urihttps://doi.org/10.1179/016911106779499028
dc.identifier.urihttps://hdl.handle.net/11616/90523
dc.identifier.volume18en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherManey Publishingen_US
dc.relation.ispartofPain Clinicen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnaesthesiaen_US
dc.subjectDexmedetomidineen_US
dc.subjectMorphine consumptionen_US
dc.subjectPostoperative painen_US
dc.titleThe effects of intra-operative low-dose dexmedetomidine infusion on postoperative pain in patients undergoing septorhinoplastyen_US
dc.typeArticleen_US

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