Preoperative predictive factors affecting sentinel lymph node positivity in breast cancer and comparison of their effectiveness with existing nomograms

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dc.authoridCeylan, Cengiz/0000-0003-3471-8726
dc.authoridpehlevan özel, hikmet/0000-0002-9146-3742
dc.authorwosidCeylan, Cengiz/AAC-7461-2022
dc.authorwosidMenekşe, Ebru/GVS-5841-2022
dc.authorwosidpehlevan özel, hikmet/HME-1647-2023
dc.contributor.authorCeylan, Cengiz
dc.contributor.authorOzel, Hikmet Pehlevan
dc.contributor.authorAgackiran, Ibrahim
dc.contributor.authorOzdemir, Buket Altun
dc.contributor.authorAtas, Hakan
dc.contributor.authorMenekse, Ebru
dc.date.accessioned2024-08-04T20:53:13Z
dc.date.available2024-08-04T20:53:13Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThis study aimed to establish a strong regression model by revealing the preoperative predictive factors for sentinel lymph node (SLN) positivity in patients with early stage breast cancer (ESBC). In total, 445 patients who underwent SLN dissection for ESBC were included. All data that may be potential predictors of SLN positivity were retrospectively analyzed. Tumor size >2 cm, human epidermal growth factor receptor 2 (HER2) + status, lymphovascular invasion (LVI), palpable tumor, microcalcifications, multifocality or multicentricity, and axillary ultrasonographic findings were defined as independent predictors of SLN involvement. The area under the receiver operating characteristic (ROC) curve (AUC) values were 0.797, 0.808, and 0.870 for the Memorial Sloan-Kettering Cancer Center (MSKCC) nomogram, MD Anderson Cancer Center (MDACC) nomogram, and our regression model, respectively (P < .001). The recent model for predicting SLN status in ESBC was found to be stronger than existing nomograms. Parameters not included in current nomograms, such as palpable tumors, microcalcifications, and axillary ultrasonographic findings, are likely to make this model more meaningful.en_US
dc.identifier.doi10.1097/MD.0000000000032170
dc.identifier.issn0025-7974
dc.identifier.issn1536-5964
dc.identifier.issue48en_US
dc.identifier.pmid36482614en_US
dc.identifier.scopus2-s2.0-85143562724en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.1097/MD.0000000000032170
dc.identifier.urihttps://hdl.handle.net/11616/101041
dc.identifier.volume101en_US
dc.identifier.wosWOS:000895502600009en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofMedicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectbreast canceren_US
dc.subjectnomogramen_US
dc.subjectrisk estimationen_US
dc.subjectsentinel lymph node dissectionen_US
dc.titlePreoperative predictive factors affecting sentinel lymph node positivity in breast cancer and comparison of their effectiveness with existing nomogramsen_US
dc.typeArticleen_US

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