Brain natriuretic peptide and severity of disease in non-alcoholic cirrhotic patients

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dc.authoridHilmioğlu, Fatih/0000-0002-6440-5686
dc.authoridKarincaoglu, Melih/0000-0002-9727-5128
dc.authorwosidHilmioğlu, Fatih/AAJ-4437-2021
dc.contributor.authorYildiz, R
dc.contributor.authorYildirim, B
dc.contributor.authorKarincaoglu, M
dc.contributor.authorHarputluoglu, M
dc.contributor.authorHilmioglu, F
dc.date.accessioned2024-08-04T20:14:52Z
dc.date.available2024-08-04T20:14:52Z
dc.date.issued2005
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: Cirrhotic patients have a hyperdynamic systemic circulation. They have insidious cardiac problems besides well-known complications. Brain natriuretic peptide (BNP) relaxes vascular smooth muscle and has a portal hypotensive action. The relations between BNP levels and severity of disease, cardiac dysfunction and esophageal varices were studied in non-alcoholic cirrhotic patients. Methods: Fifty-two non-alcoholic cirrhotic patients were evaluated for decompensation component of cirrhosis. The BNP concentration of echocardiographically examined patients was determined. Results: The BNP levels were significantly higher in ascites, spontaneous bacterial peritonitis and hepatic encephalopathy history group (P = 0.033, P < 0.001, P = 0.014, respectively), but no significant difference were observed for presence of esophageal varices and bleeding history (P = 0.267, P = 0.429). A significant correlation was observed between BNP concentration and Child score (r = 0.427, P = 0.012), interventricular septal thickness (r = 0.497, P < 0.001) and left ventricular posterior wall thickness (r = 0.526, P < 0.001). According to Child-Pugh classification there were no significant difference between groups for echocardiographic measurements and blood pressure (P > 0.05), but plasma BNP levels were significantly higher in Child class B and C patients compared with class A patients (P < 0.05). Conclusion: Increased levels of BNP are more likely related to the severity of disease in non-alcoholic cirrhotic patients. The advanced cirrhosis is associated with more advanced cardiac dysfunction and BNP has prognostic value in progression of cirrhosis. (C) 2005 Blackwell Publishing Asia Pty Ltd.en_US
dc.identifier.doi10.1111/j.1440-1746.2005.03906.x
dc.identifier.endpage1120en_US
dc.identifier.issn0815-9319
dc.identifier.issn1440-1746
dc.identifier.issue7en_US
dc.identifier.pmid15955223en_US
dc.identifier.scopus2-s2.0-21844451930en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1115en_US
dc.identifier.urihttps://doi.org/10.1111/j.1440-1746.2005.03906.x
dc.identifier.urihttps://hdl.handle.net/11616/93997
dc.identifier.volume20en_US
dc.identifier.wosWOS:000229519000022en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Gastroenterology and Hepatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectascitesen_US
dc.subjectbrain natriuretic peptideen_US
dc.subjectcardiomyopathyen_US
dc.subjectesophageal varicesen_US
dc.subjectliver cirrhosisen_US
dc.titleBrain natriuretic peptide and severity of disease in non-alcoholic cirrhotic patientsen_US
dc.typeArticleen_US

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