The effect of cinnamon bark oil in bilateral common carotid artery occlusion-induced cerebral ıischemia model in rats
Küçük Resim Yok
Tarih
2025
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Nature Portfolio
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
This study aimed to evaluate the protective and therapeutic effects of Cinnamon Bark Oil (CBO) on cerebral ischemia/reperfusion (I/R) injury in rats. The focus was on its potential antioxidant, anti-inflammatory, and antiapoptotic properties. Forty-four female Wistar albino rats were divided into four groups: Sham + CBO group, I/R + Vehicle group, prophylactic (CBO + I/R) group and therapeutic (I/R + CBO) group. Bilateral common carotid artery occlusion was performed to induce ischemia, followed by reperfusion for 72 h. CBO (100 mg/kg) was administered orally. Biochemical, histopathological, and immunohistochemical analyses were conducted, measuring oxidative stress markers, inflammatory cytokines, and neuronal degeneration in the cerebral cortex and hippocampus. Histopathological analysis revealed that CBO significantly reduced neuronal degeneration in both the prophylactic and therapeutic groups. Biochemically, CBO increased superoxide dismutase (SOD) and total antioxidant capacity (TAC), while decreasing malondialdehyde (MDA) and tumor necrosis factor-alpha (TNF-alpha) levels. Immunohistochemical staining showed decreased apoptotic markers (caspase-3, Bax) in the prophylactic and therapeutic groups. CBO demonstrated neuroprotective effects in cerebral I/R injury through its antioxidant, anti-inflammatory, and antiapoptotic properties. These findings suggest its potential as a complementary therapeutic agent for ischemic brain injuries.
Açıklama
Anahtar Kelimeler
Cerebral ischemia, Reperfusion injury, Cinnamon bark oil, Antioxidant, Anti-inflammatory, Anti-apoptotic
Kaynak
Scientific Reports
WoS Q Değeri
Q1
Scopus Q Değeri
N/A
Cilt
15
Sayı
1
