Serum levels of TNF-?, sIL-2R, IL-6, and IL-8 are increased and associated with elevated lipid peroxidation in patients with Behcet's disease

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dc.authoridTürköz, Yusuf/0000-0001-5401-0720
dc.authorwosidEvereklioğlu, Cem/A-5370-2018
dc.authorwosidcekmen, mustafa baki/G-6122-2011
dc.authorwosidTürköz, Yusuf/ABG-7931-2020
dc.contributor.authorEvereklioglu, C
dc.contributor.authorEr, H
dc.contributor.authorTürköz, Y
dc.contributor.authorÇekmen, M
dc.date.accessioned2024-08-04T20:12:20Z
dc.date.available2024-08-04T20:12:20Z
dc.date.issued2002
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAIM Behcet's disease (BD) is a systemic immunoinflammatory disorder and the aetiopathogenesis is to be specified. Cytokines play a role in immune response and in many inflammatory diseases. The aim of this case-control study is to investigate serum pro-inflammatory cytokine tumour necrosis factor (TNF)-alpha, interleukin-1beta (IL-1beta), soluble IL-2 receptor (sIL-2R), IL-6, and chemokine IL-8 levels in patients with BD. We also determined the end product of lipid peroxidation (malondialdehyde (MDA)) in BD patients as an index for oxidative stress. Methods: A total of 37 patients (19 men, 18 women) with BD (active, n = 17; inactive, n = 20) and 20 age-matched and sex-matched healthy control subjects (11 men, nine women) included in this cross-sectional, blinded study. Serum TNF-alpha, IL-1beta, sIL-2R, IL-6 and IL-8 levels were determined by a spectrophotometer technique using the immulite chemiluminescent immunometric assay. Lipid peroxidation was evaluated by Wasowicz et al. The levels of cytokines and lipid peroxidation in the active period were compared with the inactive period of the disease. Results are expressed as mean +/- standard error. Results: IL-1beta levels were below the detection limits of the assay (< 5 pg/ml) in all samples. Mean levels of MDA (8.1 +/- 0.7 ?mol/l), sIL-2R (800 +/- 38 U/ml), IL-6 (12.6 +/- 1.1 pg/ml), IL-8 (7.2 +/- 0.4 pg/ml), and TNF-? (7.9 +/- 0.5 pg/ml) in active BD patients were significantly higher than those in inactive patients (4.3 +/- 0.5 ?mol/l, p < 0.01; 447 +/- 16 U/ml, p < 0.001; 8.3 +/- 0.6 pg/ml, p = 0.006; 5.3 +/- 0.1 pg/mL p < 0.001; and 5.1 +/- 0.2 pg/ml, p < 0.001; respectively) or control subjects (2.1 +/- 0.2 ?mol/l, p < 0.001; 446 +/- 20 U/ml, p < 0.001; 6.4 +/- 0.2 pg/ml, p < 0.001; 5.4 +/- 0.1 pg/ml, p < 0.001; and 4.7 +/- 0.1 pg/ml, p < 0.001, respectively). On the contrary, only the mean IL-6 level was significantly different between inactive BD and control subjects (p = 0.02). All acute phase reactants were significantly higher in active BD than in inactive period (for each,p < 0.01). Conclusions: High levels of sIL-2R, IL-6, IL-8 and TNF-? indicate the activation of immune system in BD. Serum sIL-2R, IL-6, IL-8 and TNF-? seem to be related to disease activity. Increased lipid peroxidation suggests oxidative stress in BD and therefore tissue damage in such patients. Amelioration of clinical manifestations would be envisaged by targeting these cytokines, chemokines and lipid peroxidation with pharmacological agents.en_US
dc.identifier.doi10.1080/09629350220131935
dc.identifier.endpage93en_US
dc.identifier.issn0962-9351
dc.identifier.issue2en_US
dc.identifier.pmid12061429en_US
dc.identifier.scopus2-s2.0-0036096375en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage87en_US
dc.identifier.urihttps://doi.org/10.1080/09629350220131935
dc.identifier.urihttps://hdl.handle.net/11616/93376
dc.identifier.volume11en_US
dc.identifier.wosWOS:000175495000004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherCarfax Publishingen_US
dc.relation.ispartofMediators of Inflammationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBehcet's diseaseen_US
dc.subjectchemokineen_US
dc.subjectcytokineen_US
dc.subjectimmunoassayen_US
dc.subjectinterleukinen_US
dc.subjectlipid peroxidationen_US
dc.titleSerum levels of TNF-?, sIL-2R, IL-6, and IL-8 are increased and associated with elevated lipid peroxidation in patients with Behcet's diseaseen_US
dc.typeArticleen_US

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