Evaluation of plasma zonulin level and its relationship with inflammatory cytokines in patients with vitiligo

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dc.authoridAltunisik, Nihal/0000-0001-6844-1097
dc.authoridTürkmen, Dursun/0000-0001-9076-4669
dc.authoridUremis, Muhammed Mehdi/0000-0003-2296-2422
dc.authoridTürköz, Yusuf/0000-0001-5401-0720
dc.authoridARSLAN, SELAMI/0000-0003-2500-633X
dc.authorwosidAltunisik, Nihal/ABG-8567-2020
dc.authorwosidTürkmen, Dursun/ABG-3801-2020
dc.authorwosidli, juqian/KII-7123-2024
dc.authorwosidUremis, Muhammed Mehdi/HKP-0531-2023
dc.authorwosidTürköz, Yusuf/ABG-7931-2020
dc.contributor.authorArslan, Selami
dc.contributor.authorAltunisik, Nihal
dc.contributor.authorTurkmen, Dursun
dc.contributor.authorUremis, Muhammed M.
dc.contributor.authorSener, Serpil
dc.contributor.authorTurkoz, Yusuf
dc.date.accessioned2024-08-04T20:53:11Z
dc.date.available2024-08-04T20:53:11Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground It has been proven that there is an increase in intestinal permeability in some autoimmune diseases. In our study, we purposed to assess intestinal permeability in vitiligo disease by looking at zonulin levels. At the same time, we aimed to examine the correlation of inflammatory cytokines and lipopolysaccharide (LPS) levels with zonulin. Methods Forty-one patients and 41 healthy participants were involved in our study. Blood samples were taken from all patients and controls, and the levels of zonulin, tumor necrosis factor (TNF)-alpha, interleukin (IL)-6 and LPS were examined. Results The mean of zonulin in the patient group was found to be statistically higher than the control group (p < 0.05). A positive correlation was found between zonulin level and IL-6, TNF-alpha, and LPS levels (p < 0.05). TNF-alpha and LPS levels in the vitiligo group were significantly higher than in the control group, but there was no such significance in terms of IL-6 levels. Conclusion We think that serum zonulin level increases and intestinal permeability increases in vitiligo disease.en_US
dc.description.sponsorshipInonu University Scientific Research Project Coordination Uniten_US
dc.description.sponsorshipInonu University Scientific Research Project Coordination Uniten_US
dc.identifier.doi10.1111/jocd.15493
dc.identifier.endpage1016en_US
dc.identifier.issn1473-2130
dc.identifier.issn1473-2165
dc.identifier.issue3en_US
dc.identifier.pmid36370419en_US
dc.identifier.scopus2-s2.0-85142045065en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1011en_US
dc.identifier.urihttps://doi.org/10.1111/jocd.15493
dc.identifier.urihttps://hdl.handle.net/11616/100999
dc.identifier.volume22en_US
dc.identifier.wosWOS:000882044800001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Cosmetic Dermatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectintestinal permeabilityen_US
dc.subjectlipopolysaccharideen_US
dc.subjectvitiligoen_US
dc.subjectzonulinen_US
dc.titleEvaluation of plasma zonulin level and its relationship with inflammatory cytokines in patients with vitiligoen_US
dc.typeArticleen_US

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