Effects of molsidomine on retinopathy and oxidative stress Induced by radiotheraphy in rat eyes

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dc.authoridTR221045en_US
dc.authoridTR110959en_US
dc.authoridTR158691en_US
dc.authoridTR102000en_US
dc.authoridTR45132en_US
dc.authoridTR125476en_US
dc.authoridTR58662en_US
dc.contributor.authorÖzer, Murat Atabey
dc.contributor.authorPolat, Nihat
dc.contributor.authorÖzen, Serkan
dc.contributor.authorEkici, Kemal
dc.contributor.authorPolat, Alaaddin
dc.contributor.authorVardı, Nigar
dc.contributor.authorTanbek, Kevser
dc.contributor.authorYıldız, Azibe
dc.contributor.authorParlakpınar, Hakan
dc.date.accessioned2017-04-10T13:33:03Z
dc.date.available2017-04-10T13:33:03Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPurpose: To determine the role of Molsidomine in preventing radiation-induced retinopathy after head and neck region irradiation of rats with a single radiation dose of 15 Gy. Male Wistar albino rats were randomly grouped into five as follows: (1) control group rats, which were applied through an intraperitoneal (i.p.) vehicle without radiotherapy (RT); (2) RT group rats received a single dose of 15 Gy irradiation and after daily 0.1 ml vehicle i.p. for 5 consecutive days; (3) molsidomine (MOL) group rats were treated for 5 consecutive days by i.p. with 4 mg/kg/day MOL; (4) irradiation plus MOL group (RT+MOL) rats received irradiation and after 10 days single daily i.p. dose of MOL for 5 consecutive days; and (5) MOL+RT group rats were treated for 5 consecutive days by i.p. with MOL before RT. At the end of the work the rats were sacrificed under high-dose anesthesia on the 16th day and then eye tissues were taken for histopathological, immunohistochemical (caspase-3), and biochemical analyses (superoxide dismutase [SOD], glutathione peroxidase [GSH], and malondialdehyde [MDA]). RT significantly decreased both the content of GSH and the activity of SOD, and significantly increased the production of MDA level in the rat eyes. MOL treatment significantly increased the SOD and GSH levels and significantly decreased the MDA production (p < 0.0001). In addition, RT significantly increased the number of ganglion cells (GCs; p = 0.001), whereas especially pretreatment with MOL improved (p = 0.013). RT led to significant retinopathy formation, and MOL therapy protected the retina from radiation-induced retinopathy (p < 0.0001). We suggest that MOL is a powerful antioxidant and free radical scavenger that prevents the rat eyes from radiation-induced retinopathy and oxidative stress.en_US
dc.identifier.citationÖzer, M. A., Polat, N., Özen, S., Parlakpınar, H., Ekici, K., Polat, A., Vardı, N. Tanbek, K. YILDIZ, A. (2016). Effects of Molsidomine on Retinopathy and Oxidative Stress Induced by Radiotheraphy in Rat Eyes. Current Eye Research, 1–7.en_US
dc.identifier.doi10.1080/02713683.2016.1238943en_US
dc.identifier.issn0271-3683
dc.identifier.issue7en_US
dc.identifier.urihttps://www.tandfonline.com/doi/full/10.1080/02713683.2016.1238943
dc.identifier.urihttps://hdl.handle.net/11616/6611
dc.identifier.volume1en_US
dc.language.isoenen_US
dc.publisherCurrent Eye Researchen_US
dc.relation.ispartofCurrent Eye Researchen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntioxidanten_US
dc.subjectApoptosisen_US
dc.subjectİonizing radiationen_US
dc.subjectMolsidomineen_US
dc.subjectOxidative stressen_US
dc.titleEffects of molsidomine on retinopathy and oxidative stress Induced by radiotheraphy in rat eyesen_US
dc.typeArticleen_US

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