Comparison of patients with fulminant versus near-miss fulminant drug-induced hepatitis

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dc.authoridÇOLAK, CEMİL/0000-0001-5406-098X
dc.authoridCagin, Yasir Furkan/0000-0002-2538-857X
dc.authoridAkbulut, Sami/0000-0002-6864-7711
dc.authoridbilgic, yılmaz/0000-0002-2169-5548
dc.authoridYildirim, Oguzhan/0000-0001-8254-0104
dc.authoridHarputluoglu, Muhsin Murat Muhip/0000-0002-9415-147X;
dc.authorwosidÇOLAK, CEMİL/ABI-3261-2020
dc.authorwosidCagin, Yasir Furkan/ABI-2709-2020
dc.authorwosidAkbulut, Sami/L-9568-2014
dc.authorwosidbilgic, yılmaz/ABI-6432-2020
dc.authorwosidYildirim, Oguzhan/ABI-8174-2020
dc.authorwosidHarputluoglu, Muhsin Murat Muhip/ABI-3094-2020
dc.authorwosidSeckin, Yuksel/ABI-3468-2020
dc.contributor.authorBilgic, Yilmaz
dc.contributor.authorAkbulut, Sami
dc.contributor.authorKutlu, Orkide
dc.contributor.authorYilmaz, Cengiz
dc.contributor.authorColak, Cemil
dc.contributor.authorDeviren, Mehmet Veysi
dc.contributor.authorCagin, Yasir Furkan
dc.date.accessioned2024-08-04T20:42:56Z
dc.date.available2024-08-04T20:42:56Z
dc.date.issued2017
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThis study aimed to investigate and compare clinical and laboratory properties of patients with fulminant versus near-miss fulminant drug-induced hepatitis and the effect of these properties on mortality. Drug-induced hepatitis is the most common cause of acute liver failure in western countries. In severe drug-induced hepatitis, once encephalopathy develops, prognosis is poor without liver transplantation. Therefore, it is important to predict prognosis and know the clinical differences between patients developing encephalopathy and patients without encephalopathy. Patients with severe drug-induced hepatitis were researched retrospectively. The identified patients were divided into two groups: with encephalopathy (fulminant hepatitis; 25 patients) and without encephalopathy (near-miss fulminant hepatitis; 48 patients). The clinical properties and biochemical results of the two groups were compared, and parameters that could have an effect on mortality were evaluated. Hemoglobin, platelet count, albumin, and fibrinogen levels were found to be decreased, whereas, International Normalized Ratio (INR), total bilirubin, AST, LDH, lactate, and ammonia levels were found to be increased significantly in the fulminant hepatitis group. Creatinine, Model for End-Stage Liver Disease (MELD) score, and platelet count were found to be independent risk factors on mortality. The development of hepatic encephalopathy negatively impacts patient survival. Therefore, the prediction of a progression to fulminant hepatitis before hepatic encephalopathy develops and the clinical follow-up of patients accordingly are important issues. This study can provide significant insight into patients with severe drug-induced hepatitis.en_US
dc.identifier.endpage670en_US
dc.identifier.issn0970-938X
dc.identifier.issn0976-1683
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85012009456en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage663en_US
dc.identifier.urihttps://hdl.handle.net/11616/97687
dc.identifier.volume28en_US
dc.identifier.wosWOS:000393490700029en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherAllied Acaden_US
dc.relation.ispartofBiomedical Research-Indiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDrug-induceden_US
dc.subjectFulminant hepatitisen_US
dc.subjectHepatotoxicityen_US
dc.subjectNear-miss fulminant hepatitisen_US
dc.titleComparison of patients with fulminant versus near-miss fulminant drug-induced hepatitisen_US
dc.typeArticleen_US

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