Koronavirüs hastalığı 2019'un atopi ile ilişkisi
Küçük Resim Yok
Tarih
2024
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
İnönü Üniversitesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Mevcut tez çalışmasında, Koronavirüs Hastalığı 2019 (COVID-19)'un alerjik yanıtı tetikleme olasılığı incelenmiştir. Bu bağlamda, COVID-19'un ve aşılarının total ve spesifik IgE (süt ve yumurta) üzerine etkileri geliştirmiş olduğumuz ELISA test kitleriyle ölçülmüştür. Materyal ve Metot: Retrospektif olarak 4 deneme tasarımı yapıldı ve IgE seviyeleri üzerine: (1) COVID-19 sonrası geçen sürenin etkisi (ilk 4 ay, n=361), (2) COVID-19 geçiren kişilerde alerjik öykünün etkisi (n=61), (3) COVID-19 semptom şiddetinin etkisi (n=66) ile (4) COVID-19 aşılarının etkisi (n=178) incelendi. Ayrıca total ve spesifik (anti-SARS-CoV-2) IgG ölçümleri de yapıldı. Bulgular: Ortalama anti-SARS-CoV-2 IgG seviyeleri cut-off değerinden daha yüksekti. COVID-19 sonrası total IgE seviyesi ilk ay yüksek iken (p<0.05), spesifik IgE seviyeleri (yumurta beyazı ve sarısı) 2. aydan sonra artış gösterdi (p<0.05). Alerjik öykü ve COVID-19 şiddeti total IgE artışına yol açarken (p<0.05), spesifik IgE'yi etkilemedi (P>0.05). Aşılama, total IgE artışı (yalnızca alerjik kişilerde) ile birlikte yumurta sarısı (yalnızca alerjik kişilerde) ve beyazına karşı spesifik IgE artışına da yol açarken (p<0.05), süte spesifik IgE oluşumunu etkilemedi (p>0.05). Sonuç: COVID-19 ve aşılarının, total ve yumurta-spesifik IgE artışına yol açması, SARS-CoV-2 ile yumurta alerjisi arasında ilişki bulunduğunu ortaya çıkarmaktadır. Bununla beraber, bu durumun süt alerjisi için geçerli olmaması, yumurta alerjenleri ile SARS-CoV-2 virüsü arasındaki epitop benzerliğinden kaynaklanabilir. Ayrıca, COVID-19'u şiddetli geçiren kişilerde total IgE'nin artmış olması, hastalığın şiddetini azaltmak üzere anti-IgE uygulamaları yapılmasını desteklemektedir. Anahtar Kelimeler: Alerji, Anti-SARS-CoV-2 IgG, COVID-19, IgE, IgG
Aim: In the current thesis, the possibility of Coronavirus Disease 2019 (COVID-19) triggering an allergic response was examined. In this context, the effects of COVID-19 and its vaccines on total and specific IgE (milk and egg) were measured with the ELISA test kits we developed. Material and Method: Four experimental designs were constructed retrospectively to investigate: (1) The effect of the time after COVID-19 (first 4 months, n=361), (2) The effect of allergic history in people with COVID-19 (n=61), (3) the effect of COVID-19 symptom severity (n=66) and (4) the effect of COVID-19 vaccines (n=178) on IgE levels. Total and specific (anti-SARS-CoV-2) IgG levels were also measured. Results: The mean anti-SARS-CoV-2 IgG levels were higher than the cut-off value. While the total IgE level after COVID-19 was high in the first month (p<0.05), specific IgE levels (egg white and yolk) increased after the 2nd month (p<0.05). Allergic history and COVID-19 severity increased total IgE (p<0.05) but did not affect specific IgE levels (P>0.05). Vaccination increased total IgE (only allergic individuals) and specific IgE against egg yolk (only allergic individuals) and egg white (p<0.05) but it did not affect milk specific IgE (p>0.05). Conclusion: COVID-19 and its vaccines increased total and egg-specific IgE levels revealing associations between SARS-CoV-2 and egg allergy. However, this was not the case for milk allergy, most likely due to epitope similiarity between egg allergens and the SARS-CoV-2 virus. Moreover, increased total IgE in individuals with severe COVID-19 may support anti-IgE treatments to decrease its severity. Keywords: Allergy, Anti-SARS-CoV-2 IgG, COVID-19, IgE, IgG
Aim: In the current thesis, the possibility of Coronavirus Disease 2019 (COVID-19) triggering an allergic response was examined. In this context, the effects of COVID-19 and its vaccines on total and specific IgE (milk and egg) were measured with the ELISA test kits we developed. Material and Method: Four experimental designs were constructed retrospectively to investigate: (1) The effect of the time after COVID-19 (first 4 months, n=361), (2) The effect of allergic history in people with COVID-19 (n=61), (3) the effect of COVID-19 symptom severity (n=66) and (4) the effect of COVID-19 vaccines (n=178) on IgE levels. Total and specific (anti-SARS-CoV-2) IgG levels were also measured. Results: The mean anti-SARS-CoV-2 IgG levels were higher than the cut-off value. While the total IgE level after COVID-19 was high in the first month (p<0.05), specific IgE levels (egg white and yolk) increased after the 2nd month (p<0.05). Allergic history and COVID-19 severity increased total IgE (p<0.05) but did not affect specific IgE levels (P>0.05). Vaccination increased total IgE (only allergic individuals) and specific IgE against egg yolk (only allergic individuals) and egg white (p<0.05) but it did not affect milk specific IgE (p>0.05). Conclusion: COVID-19 and its vaccines increased total and egg-specific IgE levels revealing associations between SARS-CoV-2 and egg allergy. However, this was not the case for milk allergy, most likely due to epitope similiarity between egg allergens and the SARS-CoV-2 virus. Moreover, increased total IgE in individuals with severe COVID-19 may support anti-IgE treatments to decrease its severity. Keywords: Allergy, Anti-SARS-CoV-2 IgG, COVID-19, IgE, IgG
Açıklama
Anahtar Kelimeler
Allerji ve İmmünoloji, Allergy and Immunology, Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji
