SYNTHESIS AND STRUCTURAL CHARACTERIZATION OF NOVEL 2-PYRAZOLINE DERIVATIVES: EVALUATION OF THEIR ANTIPROLIFERATIVE ACTIVITY AND FLUORESCENCE PROPERTIES

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dc.authoridTok, Fatih/0000-0002-4569-008X
dc.authoridŞALVA, EMINE/0000-0002-1159-5850
dc.authoridUltav, Gozde/0000-0001-5582-3766
dc.authorwosidUltav, Gözde/JPK-6247-2023
dc.authorwosidTok, Fatih/AAA-3038-2019
dc.authorwosidKocyigit-Kaymakcioglu, Bedia/JOZ-6092-2023
dc.authorwosidŞALVA, EMINE/CAH-3062-2022
dc.contributor.authorUgras, Zefine
dc.contributor.authorTok, Fatih
dc.contributor.authorSalva, Emine
dc.contributor.authorUltav, Gozde
dc.contributor.authorKocyigit-kaymakcioglu, Bedia
dc.date.accessioned2024-08-04T20:53:32Z
dc.date.available2024-08-04T20:53:32Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIn this study, a series of novel 2-pyrazoline derivatives were synthesized and their structures were established by using spectral methods. The antiproliferative activities of compounds were investigated against human cell lines A-549 and MCF-7 by MTT assay and L-929 (mouse normal fibroblast) cell cytotoxicity was also examined. Apoptotic effects of the compounds in breast and lung cancer cells were assessed by Annexin V-FITC apoptosis assay using flow cytometry. The antiproliferative effect on lung carcinoma of the synthesized compounds was higher than breast carcinoma. Moreover, it was observed that none of the synthesized compounds have cytotoxic activity in healthy cells. Flow cytometry studies have shown that compounds induced apoptosis at high concentrations. Additionally, fluorescence cell imaging studies were performed for the first time in A-549 and MCF-7 cancer cell lines to determine the potential of the biosensor compounds by fluorescence microscopy. Compounds 4b, 4d, 4e, and 4f showed fluorescence properties by considering microscopic imaging.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUEBITAK) [221S850]en_US
dc.description.sponsorshipThis work was supported by the Scientific and Technological Research Council of Turkey (TUEBITAK). Grant No: 221S850.en_US
dc.identifier.doi10.32383/appdr/157503
dc.identifier.endpage659en_US
dc.identifier.issn0001-6837
dc.identifier.issn2353-5288
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-85150821815en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage643en_US
dc.identifier.urihttps://doi.org/10.32383/appdr/157503
dc.identifier.urihttps://hdl.handle.net/11616/101246
dc.identifier.volume79en_US
dc.identifier.wosWOS:000925006900005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherPolskie Towarzystwo Farmaceutyczneen_US
dc.relation.ispartofActa Poloniae Pharmaceuticaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectsynthesisen_US
dc.subjectpyrazolineen_US
dc.subjectstructural characterizationen_US
dc.subjectcytotoxicen_US
dc.subjectfluorescent imagingen_US
dc.titleSYNTHESIS AND STRUCTURAL CHARACTERIZATION OF NOVEL 2-PYRAZOLINE DERIVATIVES: EVALUATION OF THEIR ANTIPROLIFERATIVE ACTIVITY AND FLUORESCENCE PROPERTIESen_US
dc.typeArticleen_US

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