Is it possible to diagnose fulminant Wilson's disease with simple laboratory tests?

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dc.authoridVarol, İlknur fatma/0000-0001-5212-218X
dc.authoridGozukara Bag, Harika Gozde/0000-0003-1208-4072;
dc.authorwosidVarol, İlknur fatma/ABH-6387-2020
dc.authorwosidGozukara Bag, Harika Gozde/ABG-7588-2020
dc.authorwosidgungor, sukru/JNR-9592-2023
dc.contributor.authorGungor, Sukru
dc.contributor.authorSelimoglu, Mukadder A.
dc.contributor.authorBag, Harika G. G.
dc.contributor.authorVarol, Fatma I.
dc.date.accessioned2024-08-04T20:46:53Z
dc.date.available2024-08-04T20:46:53Z
dc.date.issued2020
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground Wilson's disease is a rare cause of acute liver failure and is highly fatal without liver transplantation. Fast and accurate diagnostic methods are needed for fulminant Wilson's disease (FWD). In this study, we aimed to develop an early, simple and accurate diagnostic method to differentiate FWD from nonwilsonian acute liver failure (NWALF) causes using routine biochemical data. Methods The medical records of 24 paediatric FWD and 120 paediatric NWALF cases diagnosed at the Department of Pediatric Gastroenterology, Hepatology, and Nutrition between January 2007 and February 2017 were retrospectively reviewed. Results Using receiver operator characteristics curve (ROC) analysis, we have determined the best cut-off point for laboratory findings in FWD. Patients meeting these cut-off points were assigned one point and others were assigned zero point. We then formed a new variable consisting of the combination of 14 variables and performed a new ROC analysis. We obtained a cut-off point of >= 4.5 for FWD. The diagnostic performance of the score was characterized by a sensitivity of 0.889, a specificity of 0.879 (P < .001). A scoring system based only on aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase, AST/ALT ratio, uric acid and haemoglobin had a best cut-off point of >= 2.5 for FWD, which had a sensitivity of 0.875, a specificity of 0.867 (P < .001). Conclusions Our study demonstrated that biochemical markers offer almost as reliable, fast and accurate diagnosis of FWD as offered by ceruloplasmin and 24-hour urinary copper.en_US
dc.identifier.doi10.1111/liv.14263
dc.identifier.endpage162en_US
dc.identifier.issn1478-3223
dc.identifier.issn1478-3231
dc.identifier.issue1en_US
dc.identifier.pmid31568639en_US
dc.identifier.scopus2-s2.0-85074026003en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage155en_US
dc.identifier.urihttps://doi.org/10.1111/liv.14263
dc.identifier.urihttps://hdl.handle.net/11616/98997
dc.identifier.volume40en_US
dc.identifier.wosWOS:000489654200001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofLiver Internationalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectchildrenen_US
dc.subjectearly diagnosisen_US
dc.subjectfulminant Wilson's diseaseen_US
dc.subjectsimple biochemical markersen_US
dc.titleIs it possible to diagnose fulminant Wilson's disease with simple laboratory tests?en_US
dc.typeArticleen_US

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