Influence of purple basil (Ocimum basilicum L.) extract and essential oil on hyperlipidemia and oxidative stress in rats fed high-cholesterol diet

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dc.authoridEr, Besir/0000-0002-9583-2218
dc.authoridŞAHİN, KAZIM/0000-0002-6459-1853
dc.authoridKanmaz, Hilal/0000-0002-9363-8454
dc.authoridHayaloglu, Ali Adnan/0000-0002-4274-2729
dc.authorwosidEr, Besir/GXV-6448-2022
dc.authorwosidŞAHİN, KAZIM/AAG-2742-2019
dc.authorwosidKanmaz, Hilal/AAA-7257-2021
dc.authorwosidHayaloglu, Ali Adnan/ABF-7063-2020
dc.contributor.authorGokce, Y.
dc.contributor.authorKanmaz, H.
dc.contributor.authorEr, B.
dc.contributor.authorSahin, K.
dc.contributor.authorHayaloglu, A. A.
dc.date.accessioned2024-08-04T20:50:25Z
dc.date.available2024-08-04T20:50:25Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe aim of this study was to investigate and compare the effects of purple basil methanolic extract and essential oil on serum lipid profiles in rats fed a high cholesterol diet. Feeding a high-cholesterol diet increased serum lipid profiles, leptin, hepatic triglyceride, cholesterol levels, malondialdehyde concentrations, fatty acid synthase (FAS), liver X receptors (LXRs), ATP-citrate lyase (ACLY), and sterol regulatory element-binding proteins (SREBP-1c) expression in the liver in rats. The extract and essential oil reduced serum triglycerides by 28.2%, 30.7%, and total cholesterol by 21.7% and 14.5%, respectively. The applications did not return the aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activities to their normal levels. Extract and feno-fibrate administration decreased serum leptin levels by 17.5% and 27.5%, respectively. The extract reduced hepatic triglyceride by 16.4% and total cholesterol by 22.1%. Fenofibrate reduced the triglyceride and hepatic total cholesterol by 25.5% and 46.3%, respectively. The decrease in MDA levels was 34.6% in those treated with the extract, and less in those who were applied essential oil. Expression of fatty acid synthase (FAS), liver X receptors (LXRs), ATP-citrate lyase (ACLY), and sterol regulatory element-binding proteins (SREBP-1c) in the liver decreased by 20.9%, 15.4%, 20.7% and 16.9%, respectively, when the extract was administered. For those treated with essential oil, the decline was 9.9%, 13.6%, 10.2%, and 12.5%. It decreased by 38.1%, 56.8%, 21.7% and 40.8% in those administered fenofibrate. The ABTS and DPPH based antioxidant activities and total phenolic contents of the extract were 67.83%, 86.98% and 57.94 +/- 0.39 mg Gallic acid equivalent (GAE), respectively. The results reveal that methanolic extract of purple basil may contain hypolipidemic and antioxidant substances and its protective effect on the liver.en_US
dc.description.sponsorshipInonu University (Malatya, Turkey) Scientific Research Project Unit (BAP) [FDK-2018-1432]; Turkish Academy of Science (TUBA, Ankara, Turkey)en_US
dc.description.sponsorshipThis study was supported by Inonu University (Malatya, Turkey) Scientific Research Project Unit (BAP, Project number FDK-2018-1432) and partly funded by Turkish Academy of Science (TUBA, Ankara, Turkey) .en_US
dc.identifier.doi10.1016/j.fbio.2021.101228
dc.identifier.issn2212-4292
dc.identifier.issn2212-4306
dc.identifier.scopus2-s2.0-85110449237en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.fbio.2021.101228
dc.identifier.urihttps://hdl.handle.net/11616/100049
dc.identifier.volume43en_US
dc.identifier.wosWOS:000703450800005en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofFood Bioscienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectOcimum basilicum L.en_US
dc.subjectHypolipidemiaen_US
dc.subjectHigh cholesterolen_US
dc.subjectAntioxidant activityen_US
dc.subjectEssential oilen_US
dc.titleInfluence of purple basil (Ocimum basilicum L.) extract and essential oil on hyperlipidemia and oxidative stress in rats fed high-cholesterol dieten_US
dc.typeArticleen_US

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