The Importance of AFP in Liver Transplantation for HCC

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dc.authoridBASKIRAN, ADIL/0000-0002-7536-1631
dc.authoridOzdemir, Fatih/0000-0003-0292-3602
dc.authoridÖZDEMİR, FATİH/0000-0003-0292-3602
dc.authorwosidBASKIRAN, ADIL/ABI-2356-2020
dc.authorwosidOzdemir, Fatih/ABH-2875-2020
dc.authorwosidÖZDEMİR, FATİH/HJI-7585-2023
dc.contributor.authorOzdemir, Fatih
dc.contributor.authorBaskiran, Adil
dc.date.accessioned2024-08-04T20:48:51Z
dc.date.available2024-08-04T20:48:51Z
dc.date.issued2020
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIntroduction The most common biomarker for HCC is serum alpha-fetoprotein (AFP). AFP is used for screening and diagnosing HCC, and also, it is used for predicting prognosis and monitoring the response to treatment. Discussion AFP secretion is associated with poor tumor histologic grade and aggressive tumor biological behavior. The risk of dropout on the waiting list for liver transplantation and the risk of tumor recurrence after liver transplantation are associated with high AFP serum levels. Therefore, using AFP levels for selecting patients to include on the liver transplantation waiting lists is critical. It is also known that a low AFP serum level before liver transplantation has limited informative value, but high AFP levels prior to liver transplantation indicate a higher risk for HCC recurrence. Conclusion AFP's performance as a screening, diagnostic, and prognostic marker for HCC is not ideal, but it is the most frequently used biomarker in the management of HCC.en_US
dc.identifier.doi10.1007/s12029-020-00486-w
dc.identifier.endpage1132en_US
dc.identifier.issn1941-6628
dc.identifier.issn1941-6636
dc.identifier.issue4en_US
dc.identifier.pmid32845425en_US
dc.identifier.scopus2-s2.0-85089898656en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1127en_US
dc.identifier.urihttps://doi.org/10.1007/s12029-020-00486-w
dc.identifier.urihttps://hdl.handle.net/11616/99494
dc.identifier.volume51en_US
dc.identifier.wosWOS:000565029400001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal of Gastrointestinal Canceren_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectalpha-Fetoproteinen_US
dc.subjectHepatocellular carcinomaen_US
dc.subjectLiver transplantationen_US
dc.titleThe Importance of AFP in Liver Transplantation for HCCen_US
dc.typeReview Articleen_US

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