Preparation and in vitro characterization of curcumin loaded Chitosan-Hyaluronic acid polyelectrolyte complex based hydrogels

Basit Öğe Kaydı
dc.authoridARISOY, SEMA/0000-0003-2798-1884
dc.authorwosidARISOY, SEMA/V-1458-2017
dc.contributor.authorArisoy, Sema
dc.contributor.authorSalva, Emine
dc.date.accessioned2024-08-04T20:54:47Z
dc.date.available2024-08-04T20:54:47Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: The manuscript aims to prepare and comprehensively characterize curcumin-loaded chitosan-hyaluronic acid polyelectrolyte complex (PEC) hydrogels through in vitro assessments. By elucidating the formulation process, physicochemical attributes, and drug release kinetics, the study contributes to the producing of curcumin loaded new drug delivery system.Significance: This approach shows the unique synergy of the chosen polymers with curcumin. The meticulous in vitro analysis of the hydrogels cements their novel attributes, underlining their potential as efficacious and biocompatible curcumin carriers.Methods: To configure the optimum formulation variables, viscosity, swelling ratio, porosity, in vitro release, cell viability, and migration rate were determined. In addition, FTIR and SEM analyses were also carried out to define the characteristic of formulations.Results: Release kinetic determination is essential in estimating the release behavior of formulation in the body. All formulations showed Higuchi release kinetics, indicating that drug release from the semi-solid matrix was diffusion controlled.Conclusion: As a result, in this study, a new formulation was produced based on a simple concept with acceptable quality parameter results promising to be conducted in the industry. [GRAPHICS]en_US
dc.description.sponsorshipInonu University Scientific Research Projects [THD-2020-2329]en_US
dc.description.sponsorshipThis work was supported by Inonu University Scientific Research Projects under the Grant [THD-2020-2329].en_US
dc.identifier.doi10.1080/03639045.2023.2265477
dc.identifier.endpage647en_US
dc.identifier.issn0363-9045
dc.identifier.issn1520-5762
dc.identifier.issue10en_US
dc.identifier.pmid37781745en_US
dc.identifier.scopus2-s2.0-85174808663en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage637en_US
dc.identifier.urihttps://doi.org/10.1080/03639045.2023.2265477
dc.identifier.urihttps://hdl.handle.net/11616/101634
dc.identifier.volume49en_US
dc.identifier.wosWOS:001089582700001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofDrug Development and Industrial Pharmacyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPecen_US
dc.subjectcurcuminen_US
dc.subjectchitosanen_US
dc.subjecthyaluronic aciden_US
dc.subjecthydrogelsen_US
dc.subjectwound healingen_US
dc.titlePreparation and in vitro characterization of curcumin loaded Chitosan-Hyaluronic acid polyelectrolyte complex based hydrogelsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu