Analysis of prognostic factors in Grade 3 endometrioid type endometrial carcinoma

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dc.authoridTOPRAK, SERHAT/0000-0003-4136-0523
dc.authoridMELEKOGLU, RAUF/0000-0001-7113-6691
dc.authoridBakay, Kadir/0000-0002-0300-0810
dc.authoridTohma, Yusuf Aytac/0000-0001-9418-4733
dc.authorwosidTOPRAK, SERHAT/AAD-7854-2021
dc.authorwosidMELEKOGLU, RAUF/AAF-1614-2019
dc.authorwosidBakay, Kadir/H-9018-2018
dc.contributor.authorSahin, Eda Adeviye
dc.contributor.authorToprak, Serhat
dc.contributor.authorSayal, Hasan Berkan
dc.contributor.authorEkinci, Tekin
dc.contributor.authorYilmaz, Ercan
dc.contributor.authorBakay, Kadir
dc.contributor.authorMelekoglu, Rauf
dc.date.accessioned2024-08-04T20:52:04Z
dc.date.available2024-08-04T20:52:04Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective To investigate the prognostic factors of patients with Grade 3 endometrioid endometrial cancer (G3EEC). Methods This four-center, retrospective study included a total of 129 women with G3EEC. Demographic, clinicopathologic, and survival data were collected. Kaplan-Meier method was used for survival analysis. Predictors of outcome were analyzed using Cox proportional hazards models. Results Median age at the time of diagnosis was 63 (range 39-87) years and median follow up was 37 (range 6-126) months. For the entire cohort, the 5-year disease-free survival (DFS) and overall survival (OS) were 54.3% and 63.6%, respectively. The 5-year DFS rates for lymphovascular space invasion (LVSI) -positive and -negative patients were 41.6% and 88.3%, respectively (P < 0.001). The 5-year OS rates for LVSI-positive and -negative patients were 54.7% and 88.3%, respectively (P = 0.001). Positive LVSI status was identified as the independent prognostic factor for decreased DFS and OS (hazard ratio [HR] 5.5, 95% confidence interval [CI] 1.65-18.86; P = 0.006 versus HR 4.4, 95% CI 1.33-14.58; P = 0.013, respectively). Conclusion LVSI seems to be an independent prognostic factor for decreased DFS and OS in G3EEC patients.en_US
dc.identifier.doi10.1002/ijgo.14277
dc.identifier.endpage726en_US
dc.identifier.issn0020-7292
dc.identifier.issn1879-3479
dc.identifier.issue3en_US
dc.identifier.pmid35598153en_US
dc.identifier.scopus2-s2.0-85132356012en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage719en_US
dc.identifier.urihttps://doi.org/10.1002/ijgo.14277
dc.identifier.urihttps://hdl.handle.net/11616/100727
dc.identifier.volume159en_US
dc.identifier.wosWOS:000814277800001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofInternational Journal of Gynecology & Obstetricsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectendometrial canceren_US
dc.subjectGrade3en_US
dc.subjectprognostic factoren_US
dc.titleAnalysis of prognostic factors in Grade 3 endometrioid type endometrial carcinomaen_US
dc.typeArticleen_US

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