Effect of streptozotocin on plasma insulin levels of rats and mice: A meta-analysis study

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dc.authorscopusid57053813100
dc.contributor.authorKoksal B.
dc.date.accessioned2024-08-04T20:02:36Z
dc.date.available2024-08-04T20:02:36Z
dc.date.issued2015
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: In the studies focusing on diabetic organisms, Streprozotocine (STZ) is a frequently used agent to induce diabetes in rats and mice. However the current studies do not represent practical importance of their statistical findings. For showing practical importance of the differences in plasma insulin levels of diabetic rats and mice induced by STZ, there should be a statistical synthesis regarding statistical findings of the studies. Aim: The purpose of this study is to make a meta-analysis of the studies on the effect of STZ on plasma insulin levels in diabetic rats and mice. Materials and methods: In this study 39 effect sizes (37 studies) about levels of plasma insulin were analyzed by calculating individual effect sizes (d) and mean effect size. Results: The effect sizes were between -13.7 and +65.3 and the mean effect size value (+9.33) represented a large effect indicating that STZ was an effective agent to significantly decrease plasma insulin levels of diabetic rats and mice. Conclusion: It can be said that the differences in plasma insulin levels between STZ-applied and no application groups has a practical importance in making animal model of diabetes. © 2015, Burcu Koksal.en_US
dc.identifier.doi10.3889/oamjms.2015.093
dc.identifier.endpage383en_US
dc.identifier.issn1857-9655
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-84941368718en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage380en_US
dc.identifier.urihttps://doi.org/10.3889/oamjms.2015.093
dc.identifier.urihttps://hdl.handle.net/11616/91821
dc.identifier.volume3en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.relation.ispartofOpen Access Macedonian Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDiabetes mellitusen_US
dc.subjectMeta-analysisen_US
dc.subjectSerum insulin levelsen_US
dc.subjectStreprozotocine (STZ)en_US
dc.titleEffect of streptozotocin on plasma insulin levels of rats and mice: A meta-analysis studyen_US
dc.typeArticleen_US

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