Prokineticin 1 and leukemia inhibitory factor mRNA expression in the endometrium of women with idiopathic recurrent pregnancy loss
Küçük Resim Yok
Tarih
2014
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier Science Inc
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective: To determine the expression patterns of prokineticin 1 (PROK1) and leukemia inhibitory factor (LIF) mRNA differ in peri-implantation endometrial tissue of women with idiopathic recurrent pregnancy loss (RPL) from normal fertile women. Design: A case-control study. Setting: University-based tertiary care center. Patient(s): 30 women with idiopathic RPL and 30 fertile controls. Intervention(s): Endometrial biopsies. Main Outcome Measure(s): Real-time polymerase chain reaction analysis for expression of PROK1 and LIF mRNA. Result(s): The expression of PROK1 and LIF was statistically significantly increased in the endometrium of the women with idiopathic RPL compared with the controls. Furthermore, increased LIF expression was observed in the endometrium of women with idiopathic RPL compared with controls. Conclusion(s): An increased mRNA expression of PROK1 and LIF could be one of the several abnormalities characterizing the endometrium in women with RPL. (C) 2014 by American Society for Reproductive Medicine.
Açıklama
Anahtar Kelimeler
Leukemia inhibitory factor (LIF), prokineticin 1 (PROK1), recurrent pregnancy loss
Kaynak
Fertility and Sterility
WoS Q Değeri
Q1
Scopus Q Değeri
Q1
Cilt
102
Sayı
4
