Hippocampal damage in sepsis induced by lipopolysaccharide: The neuroprotective effects of pregabalin in a rat model
| dc.contributor.author | Aslankoc, Rahime | |
| dc.contributor.author | Ozmen, Ozlem | |
| dc.date.accessioned | 2022-03-21T14:31:19Z | |
| dc.date.available | 2022-03-21T14:31:19Z | |
| dc.date.issued | 2022 | |
| dc.department | İnönü Üniversitesi | en_US |
| dc.description.abstract | Aim: An excessive immune response to bacterial infections can lead to sepsis, a condition with a high mortality rate. Lipopolysaccharide (LPS)-induced inflammation and oxidative stress cause hippocampal injury. We aimed to investigate the antioxidant, anti-inflammatory and neurogenic effects of pregabalin (PG) against hippocampal injury induced by LPS. Material and Methods: Twenty-four rats were divided into three different groups (Control, LPS (5 mg/kg), and LPS+PG (30 mg/kg)). Six hours after LPS administration, animals were sacrificed, and the hippocampus tissue was gathered for biochemical, histopathological, and immunohistochemical research. Results: Biochemical and immunohistochemical analyses revealed the increased levels of total oxidant status (TOS), oxidative stress index (OSI), tumor necrosis factor alpha (TNF-α), interleukin-1β (IL-1β) and decreased expressions of total antioxidant status (TAS), brain-derived neurotrophic factor (BDNF), and sirtuin-1 (SIRT-1) in LPS group. In addition, histopathological analyses detected degenerative neurons, hyperemia, and edema. Conclusion: PG treatment reversed biochemical and immunohistochemical parameters and improved hyperemia, edema, and degenerative changes. In conclusion, PG increased BDNF and SIRT-1 levels by inhibiting inflammation and oxidative stress. | en_US |
| dc.identifier.citation | Aslankoc, R., & Ozmen, O. (2022). Hippocampal damage in sepsis induced by lipopolysaccharide: The neuroprotective effects of pregabalin in a rat model. Annals of Medical Research | en_US |
| dc.identifier.uri | https://hdl.handle.net/11616/56723 | |
| dc.language.iso | en | en_US |
| dc.relation.ispartof | Annals of Medical Research | en_US |
| dc.rights | info:eu-repo/semantics/openAccess | en_US |
| dc.title | Hippocampal damage in sepsis induced by lipopolysaccharide: The neuroprotective effects of pregabalin in a rat model | en_US |
| dc.type | Article | en_US |
