Favourable effect of ?-glucan treatment against cisplatin-induced reproductive system damage in male rats

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dc.authoridaydin, muhterem/0000-0002-6494-9229
dc.authoridbasak, nese/0000-0001-5566-8321
dc.authoridKaya, Kürsat/0000-0002-6353-7791
dc.authoridTaşlidere, Aslı Cetin/0000-0003-3902-3210
dc.authoridCiftci, Osman/0000-0001-5755-3560
dc.authorwosidaydin, muhterem/W-4192-2018
dc.authorwosidbasak, nese/ABH-5495-2020
dc.authorwosidKaya, Kürsat/ABG-2848-2020
dc.authorwosidTaşlidere, Aslı Cetin/AAB-3979-2021
dc.contributor.authorKaya, Kursat
dc.contributor.authorCiftci, Osman
dc.contributor.authorAydin, Muhterem
dc.contributor.authorCetin, Asli
dc.contributor.authorBasak, Nese
dc.date.accessioned2024-08-04T20:46:02Z
dc.date.available2024-08-04T20:46:02Z
dc.date.issued2019
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe aim of this study was to investigate the potential beneficial effects of beta-glucan treatment against oxidative, histological and spermatological damage caused by cisplatin on the male reproductive system. Twenty-eight Sprague Dawley male rats were used in the study. The rats were randomly divided into four equal-sized groups: a control group, cisplatin group (7 mg/kg in a single-dose cisplatin administered intraperitoneally), beta-glucan group (beta-glucan given at a dose of 50 mg kg(-1) d(-1) for 14 day) and a cisplatin plus beta-glucan group (cisplatin and beta-glucan administered together at the same dose). Cisplatin administration induced an increase in the level of thiobarbituric acid-reactive substances, a lipid peroxidation indicator. It induced a decrease in enzymatic (superoxide dismutase, catalase and glutathione peroxidase) activities and nonenzymatic (reduced glutathione) antioxidant levels. In addition, cisplatin caused both histological and spermatological damage, as shown by a decrease in sperm motility and epididymal sperm concentrations and an increase in abnormal sperm rates. The beta-glucan treatment improved cisplatin-induced oxidative, histological and spermatological damage. This study revealed that beta-glucan treatment provided prevention against male reproductive system damage caused by cisplatin. These preventative effects were likely due to its antioxidant properties.en_US
dc.identifier.doi10.1111/and.13342
dc.identifier.issn0303-4569
dc.identifier.issn1439-0272
dc.identifier.issue9en_US
dc.identifier.pmid31274209en_US
dc.identifier.scopus2-s2.0-85068535855en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1111/and.13342
dc.identifier.urihttps://hdl.handle.net/11616/98859
dc.identifier.volume51en_US
dc.identifier.wosWOS:000474152500001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofAndrologiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectcisplatinen_US
dc.subjectoxidative stressen_US
dc.subjectspermiotoxicityen_US
dc.subjecttesticular damageen_US
dc.subjectbeta-glucanen_US
dc.titleFavourable effect of ?-glucan treatment against cisplatin-induced reproductive system damage in male ratsen_US
dc.typeArticleen_US

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