Evaluation of effectiveness and neurotoxicity of rasemic ketamine in rat sciatic nerve block model

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dc.authorscopusid57196319276
dc.authorscopusid22956895300
dc.authorscopusid52464396900
dc.authorscopusid55807973900
dc.contributor.authorAslan A.
dc.contributor.authorErdo?an Kayhan G.
dc.contributor.authorŞahin T.
dc.contributor.authorGül M.
dc.date.accessioned2024-08-04T20:00:59Z
dc.date.available2024-08-04T20:00:59Z
dc.date.issued2017
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: The aim of this study is to investigate the effects of two different doses of racemic ketamine on block times in the rat sciatic nerve block model and to determine whether ketamine leads to nerve damage. Method: Sixty-four, Sprague-Dawley female rats were included into the study. Rats were anesthetized with ether and then the sciatic nerves were exposed by lateral incision on posterior approach. A total of 7 groups were formed, including Sham and Saline (0.2 mL saline) for the first step of the study. The other groups according to the test doses were: Group B (0.1 mL 05% bupivacaine+ 0.1 mL saline); Group K1 (0.1 mL ketamine 0.5 mg kg-1+0.1 mL saline); Group K2 (0.1 mL ketamine 1 mg kg-1+0.1 mL saline); Group BK1 (0.1 mL 0.5% bupivacaine+0.1 mL ketamine 0.5 mg kg'); Group BK2 (0.1 mL 0.5% bupivacaine+0.1 mL ketamine 1 mg kg-1). An investigator blinded to the groups evaluated the durations of proprioceptive, motor, and sensorial block. After neurobehavioral examinations, the sciatic nenes were removed on 8th days, and were analysed for perineural inflammation, or nerve damage. Results: Ketamine (0.5mg kg-1) combination with bupivacaine prolonged the durations of proprioceptive, motor and sensorial block about %4l, %23, %33 rates, respectively. Ketamine (1mg kg-1) combination with bupivacaine prolonged the durations of proprioceptive, motor and sensorial block about %45, %37, %31 rates, respectively. While sole injection of ketamine to the sciatic nerve did not develop motor block, it provided a shorter proprioceptive block than other groups, and a similar duration for sensorial block. It was seen that the changes in durations of block were not dose-dependent. There were no statistical difference between groups according to neurotoxicity. Conclusion: We believe that rasemic ketamine may be a good adjuvant in terms of sciatic nerve block, however further studies are needed in terms of safety and systemic side effects in humans, in spite of the positive results of our study.en_US
dc.identifier.endpage130en_US
dc.identifier.issn1300-0578
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85032642169en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage122en_US
dc.identifier.urihttps://hdl.handle.net/11616/91148
dc.identifier.volume25en_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.publisherAnestezi Dergisien_US
dc.relation.ispartofAnestezi Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNeurotoxicityen_US
dc.subjectRasemic ketamineen_US
dc.subjectSciatic nerve blocken_US
dc.titleEvaluation of effectiveness and neurotoxicity of rasemic ketamine in rat sciatic nerve block modelen_US
dc.title.alternativeRatlarda oluşturulan siyatik sinir blo?u modelinde rasemik ketaminin etkinlik ve nörotoksisite açisindan de?erlendirilmesien_US
dc.typeArticleen_US

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