Novel benzimidazolium salts and their silver(I)-N-heterocyclic carbene complexes: synthesis, characterization and their biological properties

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dc.authoridGurbuz, Nevin/0000-0003-3201-3597
dc.authoridKarci, Huseyin/0000-0002-5709-1623
dc.authoridDundar, Muhammed/0000-0001-6509-2012
dc.authoridCHERITI, Abdelkrim/0000-0002-4972-702X
dc.authoridBelhi, Zeyneb/0000-0001-6158-3957
dc.authoridOzdemir, Ismail/0000-0001-6325-0216
dc.authorwosidGurbuz, Nevin/A-3069-2016
dc.authorwosidKarci, Huseyin/AAC-3985-2022
dc.authorwosidDundar, Muhammed/AAN-1831-2020
dc.contributor.authorBelhi, Zeyneb
dc.contributor.authorKarci, Huseyin
dc.contributor.authorDundar, Muhammet
dc.contributor.authorGurbuz, Nevin
dc.contributor.authorOzdemir, Ilknur
dc.contributor.authorKoc, Ahmet
dc.contributor.authorCheriti, Abdelkrim
dc.date.accessioned2024-08-04T20:53:21Z
dc.date.available2024-08-04T20:53:21Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThis study was conducted to synthesize and characterize 1,3-dialkyl-5,6-dimethyl-benzimidazolium salts and their silver complexes. Four novel silver(I)-N-heterocyclic carbene complexes were synthesized and characterized by mass analyses, FT-IR and NMR spectroscopy. The biological capacity of the synthesized compounds was evaluated in vitro for their antimicrobial and antitumor activities. The minimum inhibitory concentration (MIC) of the 1,3-dialkyl-5,6-dimethyl-benzimidazolium salts and their complexes was determined for E. coli, P. aeruginosa, S. aureus, C. glabrata and C. albicans in vitro through BMD (Broth Microdilution). The results indicated that silver(I)-NHC complexes exhibit antimicrobial activity. In particular, complex 3c presented a significant broad-spectrum antimicrobial activity. The anticancer properties of the synthesized compounds were evaluated against MCF-7, HCT116, SH-SY5Y and BEAS-2B cell lines. Anticancer activity measurements were carried out according to the Alamar Blue assay. Efficacy was established by comparison of the salts and silver compounds with cisplatin.en_US
dc.description.sponsorshipInonu University Research Fund [IU-BAP: FBG-2021-2562]; DGRST (Algeria); MESRS; Inonu University, Malatya, Turkiyeen_US
dc.description.sponsorshipThis study was supported by Inonu University Research Fund (IU-BAP: FBG-2021-2562). We are grateful to MESRS and DGRST (Algeria) for the scholarship with Inonu University, Malatya, Turkiye.en_US
dc.identifier.doi10.1080/00958972.2022.2164191
dc.identifier.endpage133en_US
dc.identifier.issn0095-8972
dc.identifier.issn1029-0389
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85146082895en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage120en_US
dc.identifier.urihttps://doi.org/10.1080/00958972.2022.2164191
dc.identifier.urihttps://hdl.handle.net/11616/101108
dc.identifier.volume76en_US
dc.identifier.wosWOS:000908135000001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofJournal of Coordination Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectN-Heterocyclic carbeneen_US
dc.subjectbenzimidazolium saltsen_US
dc.subjectmorpholinoethylen_US
dc.subjectsilver(I)-NHC complexesen_US
dc.subjectantimicrobial and antitumor activitiesen_US
dc.titleNovel benzimidazolium salts and their silver(I)-N-heterocyclic carbene complexes: synthesis, characterization and their biological propertiesen_US
dc.typeArticleen_US

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