Nerolidol attenuates dehydroepiandrosterone-induced polycystic ovary syndrome in rats by regulating oxidative stress and decreasing apoptosis

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dc.authoridDoğan, Ayşegül/0000-0003-4160-2270
dc.authoridHayal, Taha Bartu/0000-0003-1369-2715;
dc.authorwosidDoğan, Ayşegül/AAD-3223-2019
dc.authorwosidHayal, Taha Bartu/JXL-1790-2024
dc.authorwosidYaşar, Şeyma/ABI-8055-2020
dc.contributor.authorTurkmen, Nese Basak
dc.contributor.authorYuce, Hande
dc.contributor.authorAydin, Muhterem
dc.contributor.authorTaslidere, Asli
dc.contributor.authorDogan, Aysegul
dc.contributor.authorOzek, Dilan Askin
dc.contributor.authorHayal, Taha Bartu
dc.date.accessioned2024-08-04T20:53:21Z
dc.date.available2024-08-04T20:53:21Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAims: Although nerolidol (NRL) is a naturally occurring sesquiterpene alcohol with many pharmacological ac-tivities, its role in dehydroepiandrosterone DHEA-induced polycystic ovary syndrome PCOS is unknown. This study aims to explore the potential beneficial effects and underlying molecular mechanisms of nerolidol treat-ment on polycystic ovary syndrome.Main methods: Pre-pubertal female Sprague-Dawley rats were randomly assigned into four groups (n = 8/group); group I: control; group II: PCOS; group III: P + NRL; group IV: NRL. Biochemical parameters related to oxidative stress, inflammation, apoptosis, and hormones were estimated in the blood and ovarian tissues. Histopatho-logical, ultrastructural, and immunohistochemical analyses were performed. Bax, P53, Cas-3, and Bcl-2 gene expression levels were detected with RT-PCR. The membrane array analysis detected chemokine, cytokine, and growth factor protein profiles.Key findings: In light of the available data, it can deduce that nerolidol has a significant ameliorating effect on lipid peroxidation, oxidative stress, inflammation, histopathological damage, and apoptosis accompanying PCOS in female rats.Significance: PCOS is not only a reproductive pathology but also a systemic condition and its etiopathogenesis is still not fully understood. Since changes in PCOS have important long-term effects on health, this study evaluated the efficacy of nerolidol, a phytotherapeutic for the control of biochemical, apoptotic, histopathological, and metabolic changes.en_US
dc.description.sponsorshipInonu University Department of Scientific Research Projects [TCD-2020-2090]en_US
dc.description.sponsorshipThis study was supported by the Inonu University Department of Scientific Research Projects (Project number: TCD-2020-2090, Turkiye) .en_US
dc.identifier.doi10.1016/j.lfs.2023.121380
dc.identifier.issn0024-3205
dc.identifier.issn1879-0631
dc.identifier.pmid36640898en_US
dc.identifier.scopus2-s2.0-85146280015en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.lfs.2023.121380
dc.identifier.urihttps://hdl.handle.net/11616/101116
dc.identifier.volume315en_US
dc.identifier.wosWOS:000923165300001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofLife Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNerolidolen_US
dc.subjectPolycystic ovary syndromeen_US
dc.subjectOxidative stressen_US
dc.subjectApoptosisen_US
dc.subjectDehydroepiandrosteroneen_US
dc.titleNerolidol attenuates dehydroepiandrosterone-induced polycystic ovary syndrome in rats by regulating oxidative stress and decreasing apoptosisen_US
dc.typeArticleen_US

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