New derivatives of benzimidazole and their antimicrobial activity

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dc.authoridDURMAZ, RIZA/0000-0001-6561-778X
dc.authorwosidDURMAZ, Rıza/HJH-4918-2023
dc.contributor.authorCetinkaya, E
dc.contributor.authorAlici, B
dc.contributor.authorGök, Y
dc.contributor.authorDurmaz, R
dc.contributor.authorGünal, S
dc.date.accessioned2024-08-04T20:12:01Z
dc.date.available2024-08-04T20:12:01Z
dc.date.issued1999
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAzolium salts and neutral 2-aryl derivatives of benzimidazole, benzothiazole and benzoxazole were synthesized and compounds were identified by H-1 and C-13 NMR spectroscopy and microanalytical methods. In this work the salts I and the neutral compounds 2 were evaluated for their in vitro antimicrobial activity against standard strains: Enterococcus faecalis (ATCC 29212), Staphylococcus aureus (ATCC 29213), Escherichia coli (ATCC 25922), Pseudomonas aeruginosa (ATCC 27853), Candida albicans and Candida tropicals. The compounds If, Ig, Il, Im, In, 2a, 2b, 2c, 2e, 2f showed antimicrobial activity against Enterococcus faecalis (ATCC 29212), Staphylococcus aureus (ATCC 29213), Escherichia coli (ATCC 25922), Pseudomonas aeruginosa (ATCC 27853), Candida albicans and Candida tropicals, with minimum inhibitory concentrations (MICs) ranging between 50 to 200 mu g/mL. Compounds If, Ig, 11, Im, 2b, 2e showed the highest activity. Benzothiazolium and benzoxazolium salts were more active than 1,3-disubstituted benzimidazolium salts and neutral 2-substituted benzimidazole, benzothiazole and benzoxazole derivatives.en_US
dc.identifier.endpage89en_US
dc.identifier.issn1120-009X
dc.identifier.issue2en_US
dc.identifier.pmid10326736en_US
dc.identifier.scopus2-s2.0-0032952961en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage83en_US
dc.identifier.urihttps://hdl.handle.net/11616/93168
dc.identifier.volume11en_US
dc.identifier.wosWOS:000079929300001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherE I F T Srlen_US
dc.relation.ispartofJournal of Chemotherapyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectantimicrobialsen_US
dc.subjectbenzimidazoleen_US
dc.subjectbenzothiazoleen_US
dc.subjectbenzoxazole derivativesen_US
dc.titleNew derivatives of benzimidazole and their antimicrobial activityen_US
dc.typeArticleen_US

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