Effects of Electroconvulsive Therapy on Some Inflammatory Factors in Patients With Treatment-Resistant Schizophrenia

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dc.authoriderbay, lale gönenir/0000-0002-9969-3016
dc.authoridbay karabulut, aysun/0000-0002-7873-2805
dc.authoridAcar, Ceren/0000-0003-1842-9203
dc.authoridkartalcı, şükrü/0000-0003-2560-0355
dc.authorwosidAcar, Ceren/B-5758-2008
dc.authorwosiderbay, lale gönenir/AAE-6285-2019
dc.authorwosidbay karabulut, aysun/HJP-0995-2023
dc.authorwosidAcar, Ceren/M-2926-2019
dc.authorwosidkartalcı, şükrü/ABI-1106-2020
dc.contributor.authorKartalci, Sukru
dc.contributor.authorKarabulut, Aysun Bay
dc.contributor.authorErbay, Lale Gonenir
dc.contributor.authorAcar, Ceren
dc.date.accessioned2024-08-04T20:41:31Z
dc.date.available2024-08-04T20:41:31Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjectives Electroconvulsive therapy (ECT) is the most effective option for several psychiatric conditions, including treatment-resistant schizophrenia. However, little is known about the molecular mechanism of action of ECT. The link between inflammatory system and schizophrenia is the focus of recent studies. However, the impact of ECT on inflammatory functioning in this disorder remains elusive. Whether ECT could modulate inflammatory factors in patients with schizophrenia was examined. Methods Plasma levels of interleukin-4 (IL-4), transforming growth factor- (TGF-), myeloperoxidase (MPO), and nuclear factor-B (NF-B) activation were analyzed in 20 schizophrenic patients, mainly with resistant to antipsychotic medication disorders, and in 20 sex- and age-matched healthy controls. Disease severity was evaluated using the Brief Psychiatric Rating Scale. All patients were followed with measurement of the inflammatory factors before and after ECT treatment and compared with the controls. Results Patients with schizophrenia had markedly raised NF-B and but decreased TGF- levels compared with healthy controls. On the other hand, no significant differences were found for the levels of IL-4 and MPO levels. The clinical improvement during repeated ECT was accompanied by a gradual and significant increase in IL-4 and TGF- level, but MPO and NF-B activation were left unaffected. Increases in TGF- were negatively correlated with the change in Brief Psychiatric Rating Scale scores after ECT. Conclusions It is shown that ECT, while increasing the anti-inflammatory response such as the levels of IL-4 and TGF-, it did not affect the levels of MPO and NF-B activation in this study.en_US
dc.identifier.doi10.1097/YCT.0000000000000303
dc.identifier.endpage179en_US
dc.identifier.issn1095-0680
dc.identifier.issn1533-4112
dc.identifier.issue3en_US
dc.identifier.pmid26886746en_US
dc.identifier.scopus2-s2.0-84958787436en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage174en_US
dc.identifier.urihttps://doi.org/10.1097/YCT.0000000000000303
dc.identifier.urihttps://hdl.handle.net/11616/97183
dc.identifier.volume32en_US
dc.identifier.wosWOS:000383914300022en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofJournal of Ecten_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectECTen_US
dc.subjectschizophreniaen_US
dc.subjectinflammatory factorsen_US
dc.titleEffects of Electroconvulsive Therapy on Some Inflammatory Factors in Patients With Treatment-Resistant Schizophreniaen_US
dc.typeArticleen_US

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