Comparison of biochemical, antimicrobial and cytotoxic activities of different propolis samples from Malatya and Bilecik

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dc.authorscopusid57207723287
dc.authorscopusid57201417470
dc.authorscopusid57192103681
dc.authorscopusid57217135434
dc.authorscopusid55795586200
dc.authorscopusid8360674500
dc.authorscopusid55948870800
dc.contributor.authorKeskin M.
dc.contributor.authorKarlidag S.
dc.contributor.authorYilmaz O.
dc.contributor.authorTatlici E.
dc.contributor.authorKarabulut E.
dc.contributor.authorApohan E.
dc.contributor.authorYesilada O.
dc.date.accessioned2024-08-04T19:59:13Z
dc.date.available2024-08-04T19:59:13Z
dc.date.issued2020
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPropolis is a resinous natural mixtures collected and produced by honey bees. It is rich in essential oils and phenolic components so it has high levels of antioxidant, antimicrobial, anti-inflammatory and anti-tumoral activity. In this study the biochemical activity of propolis extracts were determined. The antimicrobial activity and cytotoxic activity of the extracts of the nine different propolis samples were invastigated. Their antimicrobial activities were tested by microdillution metod and define as minimum inhibitory concentration (MIC). Chemical composition of extracts was determined by using GC-MS equipment. Total phenolic content and antioxidant activity of the extracts was measured. Antimicrobial and cytotoxic activity of the extracts was carried out as well. All of the extracts showed antimicrobial activity on bacteria and yeasts used. Extracts had generally lower MIC values on yeasts. Therefore, yeasts were detected as more susceptible against the propolis extracts than the bacteria. Cytotoxic activity of extract were determined aganist A549 and Beas2B cell lines and IC50 values were calculated. Ma-Arapgir had the highest cytotoxic activity on A549 and Beas2B. They were determined as 6.72 and 26.44 mg/mL, respectively. It could be concluded that propolis extracts have antimicrobial and cytotoxic activity thus, propolis could be used in the treatment of cancer. © 2020 SYSCOM 18 S.R.L.. All rights reserved.en_US
dc.description.sponsorshipA549 cells were obtained from Prof. Dr. Fikrettin Sahin (Yeditepe University, Department of Genetics and Bioengineering, Istanbul/Turkey).en_US
dc.identifier.doi10.37358/RC.20.5.8144
dc.identifier.endpage362en_US
dc.identifier.issn0034-7752
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-85086369018en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage355en_US
dc.identifier.urihttps://doi.org/10.37358/RC.20.5.8144
dc.identifier.urihttps://hdl.handle.net/11616/90464
dc.identifier.volume71en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSyscom 18 SRLen_US
dc.relation.ispartofRevista de Chimieen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectA549en_US
dc.subjectAntimicrobial activityen_US
dc.subjectBeas2Ben_US
dc.subjectCytotoxic activityen_US
dc.subjectPropolisen_US
dc.titleComparison of biochemical, antimicrobial and cytotoxic activities of different propolis samples from Malatya and Bileciken_US
dc.typeArticleen_US

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