Microstructural Changes in Uterine Leiomyomas and Myometrium: A Diffusion-Weighted Magnetic Resonance Imaging Study

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dc.authoridErdem, Gülnur/0000-0003-2200-8620
dc.authoridKarakas, Hakki/0000-0002-1328-8520
dc.authorwosidErdem, Gülnur/GPS-7725-2022
dc.contributor.authorErdem, Gulnur
dc.contributor.authorCelik, Onder
dc.contributor.authorKarakas, Hakki Muammer
dc.contributor.authorHascalik, Seyma
dc.contributor.authorFirat, Ahmet Kemal
dc.date.accessioned2024-08-04T20:31:06Z
dc.date.available2024-08-04T20:31:06Z
dc.date.issued2009
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAlthough morphological and histopathological changes in uterine leiomyomas have been investigated in detail, the microstructural disruptions could not be studied in the living organism. Diffusion-weighted magnetic resonance imaging (DWI) is a novel tool to assess microstructural changes in vivo. The aim of this study was to investigate and characterize the diffusional property of leiomyomatous tissues with DWI. Sixteen females with a total of 21 leiomyomas were imaged with a 1.5-tesla clinical MR scanner. DWI images of leiomyomas, adjacent myometrial and myometrial tissues of healthy controls were obtained and quantified using apparent diffusion coefficient (ADC) maps. Mean ADC values of these groups were 1,201, 1,684, 1,661 mm(2)/s x 10(-6), respectively. ADC values in leiomyomas were significantly lower than those observed in the myometrium (p < 0.001). Cut-off values produced 91% sensitivity and 100% specificity. As ADC values implied the presence of cytotoxic edema in leiomyomas, the technique was found to be promising in observing temporal variations in leiomyomas and to monitor even the most subtle effects of therapeutic interventions. Copyright (C) 2009 S. Karger AG, Baselen_US
dc.identifier.doi10.1159/000195631
dc.identifier.endpage222en_US
dc.identifier.issn0378-7346
dc.identifier.issue4en_US
dc.identifier.pmid19169036en_US
dc.identifier.scopus2-s2.0-58349085766en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage217en_US
dc.identifier.urihttps://doi.org/10.1159/000195631
dc.identifier.urihttps://hdl.handle.net/11616/94734
dc.identifier.volume67en_US
dc.identifier.wosWOS:000265865200001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofGynecologic and Obstetric Investigationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectUterine leiomyomaen_US
dc.subjectMyometriumen_US
dc.subjectDiffusion-weighted imagingen_US
dc.titleMicrostructural Changes in Uterine Leiomyomas and Myometrium: A Diffusion-Weighted Magnetic Resonance Imaging Studyen_US
dc.typeArticleen_US

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