Beneficial effects of dexpanthenol on mesenteric ischemia and reperfusion injury in experimental rat model

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dc.authoridTR118674en_US
dc.authoridTR102000en_US
dc.authoridTR100549en_US
dc.authoridTR45132en_US
dc.authoridTR120721en_US
dc.authoridTR125476en_US
dc.authoridTR58662en_US
dc.contributor.authorYasir, Furkan Çağın
dc.contributor.authorAtayan, Yahya
dc.contributor.authorŞahin, Nurhan
dc.contributor.authorParlakpınar, Hakan
dc.contributor.authorPolat, Alaadin
dc.contributor.authorVardı, Nigar
dc.contributor.authorTağluk, Mehmet Emin
dc.contributor.authorTanbek, Kevser
dc.contributor.authorYıldız, Azibe
dc.date.accessioned2017-04-11T06:45:22Z
dc.date.available2017-04-11T06:45:22Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground and aim It has been reported that intestinal ischemia–reperfusion (I/R) injury results from oxidative stress caused by increased reactive oxygen species. Dexpanthenol (Dxp) is an alcohol analogue with epitelization, anti-inflammatory, antioxidant, and increasing peristalsis activities. In the present study, the aim was to investigate protective and therapeutic effects of Dxp against intestinal I/R injury. Materials and methods Overall, 40 rats were assigned into five groups including one control, one alone Dxp, and three I/R groups (40-min ischemia; followed by 2-h reperfusion). In two I/R groups, Dxp (500 mg/kg, i.m.) was given before or during ischemia. The histopathological findings including apoptotic changes, and also tissue and serum biochemical parameters levels, were determined. Oxidative stress and ileum damage were assessed by biochemical and histological examination. In the control (n ¼ 8) and alone Dxp (n ¼ 8; 500 mg/kg, i.m. of Dxp was given at least 30 min before recording), groups were incised via laparotomy, and electrical activity was recorded from their intestines. In this experiment, the effect of Dxp on the motility of the intestine was examined by analyzing electrical activity. Results In ileum, oxidant levels were found to be higher, while antioxidant levels were found to be lower in I/R groups when compared with controls. Dxp approximated high levels of oxidants than those in the control group, while it increased antioxidant values compared with I/R groups. Histopathological changes caused by intestinal I/R injury and histological improvements were observed in both groups given Dxp. In the Dxp group, electrical signal activity markedly increased compared with the control group. Conclusions Here, it was seen that Dxp had protective and therapeutic effects on intestinal I/R injury and gastrointestinal system peristaltism.en_US
dc.identifier.citationÇağın, Y. F., Atayan, Y., Şahin, N., Parlakpınar, H., Polat. A., Vardı, N. Tağluk, M. E. Tanbek, K. Yıldız, A. (2016). Beneficial effects of dexpanthenol on mesenteric ischemia and reperfusion injury in experimental rat model. Free Radical Research, 50(3), 354–365.en_US
dc.identifier.doi10.3109/10715762.2015.1126834en_US
dc.identifier.endpage365en_US
dc.identifier.issn1071-5762
dc.identifier.issue3en_US
dc.identifier.startpage354en_US
dc.identifier.urihttp://www.tandfonline.com/doi/full/10.3109/10715762.2015.1126834
dc.identifier.urihttps://hdl.handle.net/11616/6617
dc.identifier.volume50en_US
dc.language.isoenen_US
dc.publisherFree Radical Researchen_US
dc.relation.ispartofFree Radical Researchen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDexpanthenolen_US
dc.subjectIschemia– reperfusionen_US
dc.subjectIntestinal tissueen_US
dc.subjectOxidative stressen_US
dc.subjectRaten_US
dc.titleBeneficial effects of dexpanthenol on mesenteric ischemia and reperfusion injury in experimental rat modelen_US
dc.typeArticleen_US

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