Effects of cyanocobalamin on immunity in patients with pernicious anemia

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dc.authoridKAYA, Emin/0000-0001-8605-8497
dc.authoridErkurt, Mehmet Ali/0000-0002-3285-417X
dc.authorwosidKAYA, Emin/W-2951-2017
dc.authorwosidErkurt, Mehmet Ali/ABI-7232-2020
dc.contributor.authorErkurt, Mehmet Ali
dc.contributor.authorAydogdu, Ismet
dc.contributor.authorDikilitas, Mustafa
dc.contributor.authorKuku, Irfan
dc.contributor.authorKaya, Emin
dc.contributor.authorBayraktar, Nihayet
dc.contributor.authorOzhan, Onur
dc.date.accessioned2024-08-04T20:30:42Z
dc.date.available2024-08-04T20:30:42Z
dc.date.issued2008
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: The aim of the study was to evaluate the role of vitamin B-12 in patients with pernicious anemia. Materials and Methods: This study was conducted prospectively at the Turgut Ozal Medical Center, Department of Hematology, between April and November 2002. Absolute numbers and ratio of the surface antigens of T and B lymphocyte subgroups, CD4/CD8 ratio were calculated in order to evaluate changes in leukocyte and lymphocyte numbers; natural killer (NK) cell count, serum C3, C4, and levels of immunoglobulins G, A, and M were also measured to evaluate vitamin B-12 effect on immunity. Values obtained before treatment with cyanocobalamin were compared with those found during peak reticulocyte count. Results: In vitamin B-12-deficient patients, absolute numbers of CD4+ and especially CD8+ lymphocytes were found to be decreased; CD4/CD8 ratio increased, and NK cell activity was depressed. After cyanocobalamin treatment, absolute numbers and percentage of lymphocyte subgroups were elevated. Increased CD4/CD8 ratio and depressed NK cell activity were restored and levels of C3, C4, and immunoglobulins were elevated. Conclusion: These findings suggest that vitamin B-12 has important immunomodulatory effects on cellular immunity, and abnormalities in the immune system in pernicious anemia are restored by vitamin B-12 replacement therapy. Copyright (C) 2008 S. Karger AG, Basel.en_US
dc.identifier.doi10.1159/000112967
dc.identifier.endpage135en_US
dc.identifier.issn1011-7571
dc.identifier.issue2en_US
dc.identifier.pmid18287797en_US
dc.identifier.scopus2-s2.0-39749199181en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage131en_US
dc.identifier.urihttps://doi.org/10.1159/000112967
dc.identifier.urihttps://hdl.handle.net/11616/94468
dc.identifier.volume17en_US
dc.identifier.wosWOS:000253399700007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofMedical Principles and Practiceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectpernicious anemiaen_US
dc.subjectvitamin B-12en_US
dc.subjectimmunityen_US
dc.subjectnatural killer cellsen_US
dc.subjectCD4/CD8 ratioen_US
dc.titleEffects of cyanocobalamin on immunity in patients with pernicious anemiaen_US
dc.typeArticleen_US

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