Effects of resveratrol on blood homocysteine level, on homocysteine induced oxidative stress, apoptosis and cognitive dysfunctions in rats

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dc.authoridKoz, Sema T/0000-0002-6342-0200
dc.authoridonalan, ebru/0000-0001-9968-8201
dc.authoridkuloğlu, tuncay/0000-0001-9874-3838
dc.authoridBaydas, Giyasettin/0000-0002-9206-3177
dc.authorwosidBAYDAS, GIYASETTIN/AAI-4266-2021
dc.authorwosidKoz, Sema T/AAS-3664-2021
dc.authorwosidonalan, ebru/C-6463-2016
dc.authorwosidkuloğlu, tuncay/W-2310-2018
dc.contributor.authorKoz, Sema Tulay
dc.contributor.authorEtem, Ebru Onalan
dc.contributor.authorBaydas, Gyasettin
dc.contributor.authorYuce, Huseyin
dc.contributor.authorOzercan, Halil Ibrahim
dc.contributor.authorKuloglu, Tuncay
dc.contributor.authorKoz, Suleyman
dc.date.accessioned2024-08-04T20:36:11Z
dc.date.available2024-08-04T20:36:11Z
dc.date.issued2012
dc.departmentİnönü Üniversitesien_US
dc.description.abstractWe aimed to examine the protective effects of resveratrol against homocysteine induced oxidative stress, apoptosis and cognitive impairment. Rats were randomly divided into three groups. Control group received standard rat food; homocysteine group (I-Icy group) received daily methionine at a dose of 1 g/kg-body weight dissolved in drinking water for thirty days; third group (Hcy+Res group) received same amount of methionine plus 20 mg/kg/day resveratrol intraperitoneally for thirty days. Cognitive performances of the animals were tested by Morris water maze test. Then all animals were sacrificed to study lipid peroxidation (LPO), DNA fragmentation and p53 mRNA expression in the rat brain. The aortas of the sacrificed rats were processed for histopathological examination. Apoptosis in the aortas was assessed by TUNEL staining. Resveratrol significantly decreased serum levels of homocysteine, reversed Hcy induced LPO increase, decreased DNA fragmentation and p53 mRNA expression in the rat brains, and improved homocysteine induced impairment of long term spatial memory. Resveratrol could inhibit homocysteine induced apoptosis and histopathological deterioration in the rat aortic sections. In conclusion, resveratrol is effective in preventing homocysteine induced vascular and neural defects. In hyperhomocysteinemic rat model, our findings consequently warrant in future studies to reveal the true improvement mechanism of resveratrol. (C) 2012 Elsevier B.V. All rights reserved.en_US
dc.identifier.doi10.1016/j.brainres.2012.09.026
dc.identifier.endpage38en_US
dc.identifier.issn0006-8993
dc.identifier.issn1872-6240
dc.identifier.pmid22995369en_US
dc.identifier.scopus2-s2.0-84867893982en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage29en_US
dc.identifier.urihttps://doi.org/10.1016/j.brainres.2012.09.026
dc.identifier.urihttps://hdl.handle.net/11616/95827
dc.identifier.volume1484en_US
dc.identifier.wosWOS:000311175100003en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Bven_US
dc.relation.ispartofBrain Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectResveratrolen_US
dc.subjectHomocysteineen_US
dc.subjectOxidative stressen_US
dc.subjectApoptosisen_US
dc.subjectTUNELen_US
dc.subjectCognitive functionen_US
dc.titleEffects of resveratrol on blood homocysteine level, on homocysteine induced oxidative stress, apoptosis and cognitive dysfunctions in ratsen_US
dc.typeArticleen_US

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