Diffusion-weighted imaging features of brain in obesity

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dc.authoridErdem, Gülnur/0000-0003-2200-8620
dc.authoridSigirci, Ahmet/0000-0001-9221-0002
dc.authoridkeskin, lezan/0000-0001-8283-4516
dc.authoridSahin, Ibrahim/0000-0002-6231-0034
dc.authoridKarakas, Hakki/0000-0002-1328-8520
dc.authorwosidErdem, Gülnur/GPS-7725-2022
dc.authorwosidKennedy, Kristen M/B-4699-2008
dc.authorwosidSigirci, Ahmet/ABG-7387-2020
dc.authorwosidŞahin, İbrahim/HHY-8303-2022
dc.authorwosidkeskin, lezan/HJP-0902-2023
dc.authorwosidSahin, Ibrahim/ABI-6050-2020
dc.contributor.authorAlkan, Alpay
dc.contributor.authorSahin, Ibrahim
dc.contributor.authorKeskin, Lezan
dc.contributor.authorCikim, Ayse Sertkaya
dc.contributor.authorKarakas, Hakki Muammer
dc.contributor.authorSigirci, Ahmet
dc.contributor.authorErdem, Gulnur
dc.date.accessioned2024-08-04T20:30:47Z
dc.date.available2024-08-04T20:30:47Z
dc.date.issued2008
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPurpose: Obesity is characterized by an altered distribution of body fluid. However, distribution of fluid (extracellular/intracellular) in brain tissues has not been studied in obese subjects yet. The purpose of this study was to detect possible brain diffusion changes especially in satiety and hunger related centers in obese subjects by diffusion weighted imaging (DWI). Methods: Conventional MRI and DWI of the brain was obtained from 81 obese patients (obese=68, morbid obese= 13) and 29 age-matched, nonobese. The apparent diffusion coefficient (ADC) values were calculated in hypothalamus; amygdala; hippocampal gyrus-1 thalamus; insula; cingulate gyrus; orbitofrontal, dorsomedial and dorsolateral frontal, middle temporal and occipital cortex; cerebellum; midbrain and corpus striatum. Results: The ADC values of hypothalamus, hippocampal gyrus, amygdala, insula, cerebellum and midbrain were significantly increased in patients (n:81) when compared to nonobese subjects. The ADC values of thalamus, hippocampal gyrus, amygdala, orbitofrontal, occipital, dorsolateral and middle temporal cortex, insula and midbrain were significantly increased in morbid obese when compared to nonobese subjects. The ADC values of orbitofrontal and occipital cortex were significantly higher in morbid obese than the values in the obese. The body mass index positively correlated with ADC values of amygdala, insula, orbitofrontal and middle temporal cortex. Conclusion: We observed increased ADC values of distinct locations related to satiety and hunger that suggest altered fluid distribution and/or vasogenic edema in obese subjects. Awareness of this abnormalities in brain tissue composition/function in obesity may contribute to better understanding of the underlying mechanisms. (0 2008 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.mri.2007.10.004
dc.identifier.endpage450en_US
dc.identifier.issn0730-725X
dc.identifier.issn1873-5894
dc.identifier.issue4en_US
dc.identifier.pmid18063337en_US
dc.identifier.scopus2-s2.0-41949089257en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage446en_US
dc.identifier.urihttps://doi.org/10.1016/j.mri.2007.10.004
dc.identifier.urihttps://hdl.handle.net/11616/94506
dc.identifier.volume26en_US
dc.identifier.wosWOS:000255299100002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofMagnetic Resonance Imagingen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectobesityen_US
dc.subjectbrainen_US
dc.subjectdiffusion weighted imagingen_US
dc.subjectvasogenic edemaen_US
dc.titleDiffusion-weighted imaging features of brain in obesityen_US
dc.typeArticleen_US

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