Effect of angiostatin on 1,2-dimethylhydrazine-induced colon cancer in mice

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dc.authoridNisari, Mehtap/0000-0002-1126-7478
dc.authoridErtekin, Tolga/0000-0003-1756-4366
dc.authorwosidNisari, Mehtap/AAT-5486-2021
dc.authorwosidErtekin, Tolga/JBJ-0919-2023
dc.contributor.authorErtekin, Tolga
dc.contributor.authorEkinci, Nihat
dc.contributor.authorKaraca, Omur
dc.contributor.authorNisari, Mehtap
dc.contributor.authorCanoz, Ozlem
dc.contributor.authorUlger, Harun
dc.date.accessioned2024-08-04T20:37:42Z
dc.date.available2024-08-04T20:37:42Z
dc.date.issued2013
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAntiangiogenic therapy is supposed to be an attractive approach for antitumor treatment. Human plasminogen-derived angiostatin K1-3 is one of the most potent antiangiogenic agents known currently. However, it is unclear whether angiostatin has got protective effects on colon cancer. So we investigated the protective effects of angiostatin on 1,2-dimethylhydrazine (DMH)-induced colon cancer in mice. Thirty Balb/C male mice, weighing 25-30g and 8 weeks of age, were used. Twenty of the mice were treated with DMH subcutaneously (20mg/kg) once a week for 12 weeks. Six mice died during the DMH injection and surviving mice were divided into two groups (7 mice in DMH and 7 mice in DMH+angiostatin groups). In the angiostatin group, 6 weeks after the last DMH injection the animals were first treated with angiostatin (20g/mouse) intraperitoneally and then subcutaneously every 48h (5g/mouse) throughout a period of 12 weeks. The animals were killed after 30 weeks for histopathological examination. When we look at the distribution of lesions in the colon, they mainly occurred in the distal colon. The incidence of mean colonic lesions in a tumor-bearing mouse was 9.85 +/- 4.91 in those treated with DMH and 8.71 +/- 3.49 in those treated with angiostatin. The incidence of colon tumors was not significantly affected by low dose of angiostatin, and we noticed that the number of lesions decreased by 12% in DMH+angiostatin group compared to the number of the lesions in DMH group, but this decrease was not statistically significant (p>0.05). The administration period of angiostatin corresponds to the precancerous period and the reduction in the number of lesions could be important for the protective function of angiostatin in DMH+angiostain group. We assume that therapeutic effects of angiostatin are related to its doses, route of administration, frequency and administration period. In addition, we believe that combination of high doses of angiostatin with radiation, gene therapy or chemotherapy might be successful in proper tumor model.en_US
dc.description.sponsorshipInstitute of Health Science, Erciyes University, Kayseri, Turkeyen_US
dc.description.sponsorshipThis study was supported by the Institute of Health Science, Erciyes University, Kayseri, Turkey.en_US
dc.identifier.doi10.1177/0748233712440137
dc.identifier.endpage497en_US
dc.identifier.issn0748-2337
dc.identifier.issn1477-0393
dc.identifier.issue6en_US
dc.identifier.pmid22393105en_US
dc.identifier.scopus2-s2.0-84879478720en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage490en_US
dc.identifier.urihttps://doi.org/10.1177/0748233712440137
dc.identifier.urihttps://hdl.handle.net/11616/96112
dc.identifier.volume29en_US
dc.identifier.wosWOS:000320703600002en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Incen_US
dc.relation.ispartofToxicology and Industrial Healthen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectColon canceren_US
dc.subjectmiceen_US
dc.subject1en_US
dc.subject2 dimethylhydrazineen_US
dc.subjectangiostatinen_US
dc.subjectangiogenesisen_US
dc.titleEffect of angiostatin on 1,2-dimethylhydrazine-induced colon cancer in miceen_US
dc.typeArticleen_US

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