Effects of infliximab on bacterial translocation in experimental acute necrotizing pancreatitis

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dc.authoridCömert, Bilgin/0000-0002-2148-5356
dc.authoridDeveci, Mehmet Salih/0000-0001-9612-5198
dc.authoridTASCI, ILKER/0000-0002-0936-2476
dc.authoridISIK, Ahmet Turan/0000-0001-5867-6503
dc.authorwosidCömert, Bilgin/P-3030-2019
dc.authorwosidDeveci, Mehmet Salih/AAA-1343-2020
dc.authorwosidAYDIN, SEZAİ/JXX-4162-2024
dc.authorwosidTASCI, ILKER/B-7556-2009
dc.contributor.authorAydin, Sezai
dc.contributor.authorIsik, A. Turan
dc.contributor.authorUnal, Bulent
dc.contributor.authorComert, Bilgin
dc.contributor.authorOzyurt, Mustafa
dc.contributor.authorDeveci, Salih
dc.contributor.authorOzgur, Gokhan
dc.date.accessioned2024-08-04T20:36:00Z
dc.date.available2024-08-04T20:36:00Z
dc.date.issued2012
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground & objectives: Translocation of bacteria from the gut is an important factor in the development of septic complications and mortality in acute pancreatitis (AP). The present study was designed to assess the effects of infliximab treatment on bacterial translocation (BT) in experimental acute necrotizing pancreatitis. Methods: Male Sprague-Dawley rats (n=45) were allocated into three groups. AP was induced in group II (positive control, n=15) and group III (Infliximab; n=15) by retrograde injection of taurocholate into the common biliopancreatic duct. Group I rats (Sham; n=15) received normal saline infusion into the common biliopancreatic duct as placebo. Groups I and II were treated by normal saline and group HI was treated with infliximab intraperitoneally on 6, 30 and 54 h after induction of pancreatitis. All surviving animals were killed 60 h after the induction of pancreatitis, and specimens were collected for amylase measurement as well as histopathologic and microbiologic examinations. Results: Oedema, acinar cell necrosis, inflammatory infiltration, haemorrhage, fat necrosis and perivascular inflammation in group III rats were decreased with infliximab treatment when compared with group II (P<0.001). BT to mesentery lymph node in groups I, II and III were 20, 100 and 46 per cent, respectively. BT to peritoneum and pancreas in group III was lower than group II (P<0.05). Interpretation & conclusions: Infliximab administration resulted in beneficial effects on BT and histopathologic changes in the experimental necrotizing pancreatitis. Whether anti-TNF therapy has a role in prevention of complications of ANP needs to be established.en_US
dc.identifier.endpage661en_US
dc.identifier.issn0971-5916
dc.identifier.issue5en_US
dc.identifier.pmid22771595en_US
dc.identifier.scopus2-s2.0-84863212269en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage656en_US
dc.identifier.urihttps://hdl.handle.net/11616/95706
dc.identifier.volume135en_US
dc.identifier.wosWOS:000307919700011en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWolters Kluwer Medknow Publicationsen_US
dc.relation.ispartofIndian Journal of Medical Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcute necrotizing pancreatitisen_US
dc.subjectbacterial translocationen_US
dc.subjectinfliximaben_US
dc.titleEffects of infliximab on bacterial translocation in experimental acute necrotizing pancreatitisen_US
dc.typeArticleen_US

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