Hesperidin attenuates oxidative and neuronal damage caused by global cerebral ischemia/reperfusion in a C57BL/J6 mouse model

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dc.authoridAladag, M. Arif/0000-0003-3872-3741
dc.authoridTaşlidere, Aslı Cetin/0000-0003-3902-3210
dc.authoridCiftci, Osman/0000-0001-5755-3560
dc.authorwosidAladag, M. Arif/ABI-1182-2020
dc.authorwosidTaşlidere, Aslı Cetin/AAB-3979-2021
dc.contributor.authorOztanir, M. Namik
dc.contributor.authorCiftci, Osman
dc.contributor.authorCetin, Asli
dc.contributor.authorAladag, M. Arif
dc.date.accessioned2024-08-04T20:39:54Z
dc.date.available2024-08-04T20:39:54Z
dc.date.issued2014
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe aim of this study was to determine the effects of hesperidin (HP) on neuronal damage in brain tissue caused by global cerebral ischemia/reperfusion (I/R) in C57BL/J6 mice. For this purpose, a total of 40 mice were divided equally into four groups: (1) sham-operated (SH), (2) global cerebral I/R, (3) HP, and (4) HP+I/R. The SH group was used as a control. In the I/R group, the bilateral carotid arteries were clipped for 15 min, and the mice were treated with vehicle for 10 days. In the HP group, mice were administered HP (100 mg/kg) for 10 days without carotid occlusion. In the HP+I/R group, the I/R model was applied to the mice exactly as in the I/R group, and they were then treated with 100 mg/kg HP for 10 days. Cerebral I/R significantly induced oxidative stress via an increase in lipid peroxidation and a decrease in the components of the antioxidant defense system. Furthermore, cerebral I/R increased the incidence of histopathological damage and apoptosis in brain tissue. HP treatment significantly reversed the oxidative effects of I/R and inhibited the development of neurodegenerative histopathology. Therefore, the current study demonstrates that HP treatment effectively prevents oxidative and histological damage in the brain caused by global I/R. In this context, the beneficial effects of HP are likely a result of its strong antioxidant and free radical-scavenging properties. HP may be an useful treatment to attenuate the negative effects of global cerebral I/R.en_US
dc.description.sponsorshipIUBAP (Scientific Research Fund of Inonu University) [2013/205]en_US
dc.description.sponsorshipWe acknowledge the support of IUBAP (Scientific Research Fund of Inonu University) under Grant 2013/205.en_US
dc.identifier.doi10.1007/s10072-014-1725-5
dc.identifier.endpage1399en_US
dc.identifier.issn1590-1874
dc.identifier.issn1590-3478
dc.identifier.issue9en_US
dc.identifier.pmid24676696en_US
dc.identifier.scopus2-s2.0-84908357224en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1393en_US
dc.identifier.urihttps://doi.org/10.1007/s10072-014-1725-5
dc.identifier.urihttps://hdl.handle.net/11616/96583
dc.identifier.volume35en_US
dc.identifier.wosWOS:000342123300010en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer-Verlag Italia Srlen_US
dc.relation.ispartofNeurological Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGlobal cerebral I/Ren_US
dc.subjectOxidative stressen_US
dc.subjectNeuronal damageen_US
dc.subjectHesperidinen_US
dc.subjectC57BL/J6 miceen_US
dc.titleHesperidin attenuates oxidative and neuronal damage caused by global cerebral ischemia/reperfusion in a C57BL/J6 mouse modelen_US
dc.typeArticleen_US

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