The Relationship of Cognitive Performance with Oxidative Stress in Alzheimer's Disease

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dc.authorwosidULUSAL, Hasan/V-6584-2017
dc.contributor.authorYakaryilmaz, Funda Datli
dc.contributor.authorOzturk, Zeynel Abidin
dc.contributor.authorUlusal, Hasan
dc.contributor.authorTarakicoglu, Mehmet
dc.date.accessioned2024-08-04T20:52:04Z
dc.date.available2024-08-04T20:52:04Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAims: Alzheimer's disease (AD) has a complex neurodegenerative etiology and pathogenesis. In addition to oxidative stress, inflammation also plays an important role in the development of AD. In this study, we aimed to determine the total antioxidant status (TAS), total oxidation status (TOS) and oxidative stress index (OSI) levels in AD patients. We also planned to evaluate the relationship of OSI with interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha). Methods: A total of 33 subjects with AD (mean age 78.9 +/- 7.8) and 33 subjects as control (mean age 72.3 +/- 2.6) were enrolled in this cross-sectional study. TAS and TOS were assessed with commercial kits using an autoanalyzer. TNF-alpha and IL-1 beta were measured with commercial ELISA kits. Results: The AD group demonstrated significantly higher TNF-alpha, IL-1 beta, and TOS levels compared to the control group (p = 0.001, p = 0.029, p = 0.005). The mean TAS level was significantly lower in the AD group than in the control group (p = 0.007). There was a statistically significant negative correlation between TNF-alpha and ADL, IADL, MMSE (p = 0.001, p =0.003, p = 0.003). There was a statistically significant negative correlation between IL-1 beta and AIDL, as well as a positive correlation between IL-1 beta and GDS (p = 0.029, p = 0.016). Conclusion: Our study contributes to the understanding of the situation by showing that the oxidative balance is impaired in favor of oxidants in AD. A negative correlation was found between functional capacity and TNF-alpha and IL-1 beta levels in AD patients. Different therapeutic interventions that reduce the oxidant load can be considered in the treatment of AD. Copyright (C) 2022, Taiwan Society of Geriatric Emergency & Critical Care Medicine.en_US
dc.identifier.doi10.6890/IJGE.202204_16(2).0009
dc.identifier.endpage127en_US
dc.identifier.issn1873-9598
dc.identifier.issn1873-958X
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85132337118en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage122en_US
dc.identifier.urihttps://doi.org/10.6890/IJGE.202204_16(2).0009
dc.identifier.urihttps://hdl.handle.net/11616/100726
dc.identifier.volume16en_US
dc.identifier.wosWOS:000802923300013en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTaiwan Soc Geriatric Emergency & Critical Care Medicine-Tsgecmen_US
dc.relation.ispartofInternational Journal of Gerontologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAlzheimer's diseaseen_US
dc.subjectoxidative stressen_US
dc.subjectinterleukin-1 betaen_US
dc.subjecttumor necrosis factors-alphaen_US
dc.titleThe Relationship of Cognitive Performance with Oxidative Stress in Alzheimer's Diseaseen_US
dc.typeArticleen_US

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