The role of methylated adrenomedullin in enzymatic antioxidant defense response to cold stress

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dc.authorscopusid36086966900
dc.authorscopusid6602072091
dc.contributor.authorYildirim N.C.
dc.contributor.authorYurekli M.
dc.date.accessioned2024-08-04T20:00:38Z
dc.date.available2024-08-04T20:00:38Z
dc.date.issued2010
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe aim of our study was to investigate the effects of methylated adrenomedullin (met-AdM) on some antioxidant enzymes, such as catalase (CAT), glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) in rat kidney and heart tissues after cold stress treatment. Male Wistar rats were divided into 4 groups (control, met-AdM, cold stress and cold stress + met-AdM treatments). The rats were kept at room temperature, exposed to a 16/8-hours light/dark cycle. The rats were maintained at ad libitum (free) feeding habit. In met-AdM treated group, animals received intraperitoneal injection of met-AdM (2 mg/g body weight) once a day during a week. For the cold stress exposure, the rats were kept in separate cages at 10 °C for a week. Control group rats were kept at laboratory conditions. CAT, GSH-Px and SOD enzyme activities were investigated in kidney and heart tissues. In kidney tissue compared to control, CAT and GSH-Px enzyme activity was decreased but SOD was increased in met-AdM-treated group. In met-AdM+cold stress group, only the SOD enzyme activity was significantly increased but CAT and GSH-P x decreased. SOD and GSH-Px enzyme activities were increased by cold stress but CAT was decreased in kidney. In heart tissue, CAT and GSH-Px activities were decreased but SOD was increased in met-AdM-treated group compared to control. All enzyme activities were decreased in met-AdM+cold stress group as well as by cold stress in heart, with regard to control. Cold stress can disrupt the balance in an oxidant/antioxidant system and cause oxidative damage to kidney and heart tissues by altering the enzymatic and non-enzymatic antioxidant status. We can suggest that met-AdM has possible roles in regulation of stress but we need further studies revealing responses of met-AdM in different tissues.en_US
dc.identifier.endpage3145en_US
dc.identifier.issn1018-4619
dc.identifier.issue12 Ben_US
dc.identifier.scopus2-s2.0-79952636810en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage3139en_US
dc.identifier.urihttps://hdl.handle.net/11616/90891
dc.identifier.volume19en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.relation.ispartofFresenius Environmental Bulletinen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntioxidant enzymesen_US
dc.subjectCold stressen_US
dc.subjectMethylated adrenomedullinen_US
dc.subjectRaten_US
dc.titleThe role of methylated adrenomedullin in enzymatic antioxidant defense response to cold stressen_US
dc.typeArticleen_US

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