Evaluation of cytotoxic, antifungal, and larvicidal activities of different bis-sulfonamide Schiff base compounds

Basit Öğe Kaydı
dc.authoridAydın, Hasan/0000-0002-1955-6178
dc.authoridbozgeyik, ibrahim/0000-0003-1483-2580
dc.authoridCEYLAN, Onur/0000-0002-3514-5221;
dc.authorwosidAydın, Hasan/AGY-1655-2022
dc.authorwosidUslu, Uğur/AAL-2455-2020
dc.authorwosidbozgeyik, ibrahim/AAI-2723-2020
dc.authorwosidCEYLAN, Onur/AHA-9138-2022
dc.authorwosidGÜNAL, SELAMİ/HSG-2288-2023
dc.contributor.authorAydin, Hasan
dc.contributor.authorAkocak, Suleyman
dc.contributor.authorLolak, Nebih
dc.contributor.authorYumrutas, Onder
dc.contributor.authorUslu, Ugur
dc.contributor.authorBozgeyik, Ibrahim
dc.contributor.authorUckardes, Fatih
dc.date.accessioned2024-08-04T20:53:41Z
dc.date.available2024-08-04T20:53:41Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractSchiff bases (imines or azomethines) are versatile ligands synthesized from the condensation of amino compounds with active carbonyl groups and used for many pharmaceutical and medicinal applications. In our study, we aimed to determine the cytotoxic, antifungal and larvicidal activities of biologically potent bis-sulfonamide Schiff base derivatives that were re-synthesized by us. For this aim, 16 compounds were re-synthesized and tested for their cytotoxic, antifungal and larvicidal properties. Among this series, compounds A1B2, A1B4, A4B2, A4B3, and A4B4 were shown to have cytotoxic activity against tested cancer lung cell line (A549). The most potent antifungal activity was observed in compounds A2B1 and A2B2 against all fungi. A1B1 showed the strongest larvicidal effect at all concentrations at the 72nd h (100% mortality). These obtained results demonstrate that these type of bis-substituted compounds might be used as biologically potent pharmacophores against different types of diseases.en_US
dc.identifier.doi10.1002/jbt.23375
dc.identifier.issn1095-6670
dc.identifier.issn1099-0461
dc.identifier.issue8en_US
dc.identifier.pmid37129082en_US
dc.identifier.scopus2-s2.0-85157963850en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1002/jbt.23375
dc.identifier.urihttps://hdl.handle.net/11616/101334
dc.identifier.volume37en_US
dc.identifier.wosWOS:000980087800001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Biochemical and Molecular Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectantifungal activityen_US
dc.subjectcytotoxicityen_US
dc.subjectlarvicidal activityen_US
dc.subjectSchiff baseen_US
dc.titleEvaluation of cytotoxic, antifungal, and larvicidal activities of different bis-sulfonamide Schiff base compoundsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu